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SAB3501078

Sigma-Aldrich

Anti-TMIGD1 antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 29 kDa

species reactivity

rat, mouse, human

concentration

1 mg/mL

technique(s)

ELISA: suitable
immunoblotting: suitable

NCBI accession no.

NP_996663

UniProt accession no.

Q6UXZ0

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TMIGD1(388364)

General description

TMIGD1 (Transmembrane and immunoglobulin domain containing 1) is a novel adhesion molecule expressed in several organs and tissues, specifically in renal tubular epithelial cells. It is composed of two putative immunoglobulin domains, which mediates self-dimerization.

Immunogen

Antibody was raised against an 18 amino acid peptide near the center of human TMIGD1.

Application

Anti-TMIGD1 antibody produced in rabbit is suitable for immunoblot and ELISA.

Biochem/physiol Actions

TMIGD1 (Transmembrane and immunoglobulin domain containing 1) is involved in various cellular processes such as regulation of cell structure, cell-cell adhesion, and cellular movement. Its extracellular domain stabilizes the cell morphology and cell-cell interaction. TMIGD1 plays an important role in cell survival by protecting it from oxidative cell injury. It protects cells from oxidative and nutrient-deprivation-induced cell injury by stabilizing the transepithelial electric resistance and permeability of renal epithelial cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3501078.

Physical form

Supplied at 1 mg/mL in PBS with 0.02% sodim azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Koji Fujimoto et al.
Gastroenterology, 123(6), 1941-1948 (2002-11-28)
The surface epithelium of the colon is being replaced constantly with cells derived from the stem cells of the crypt. Although the location of the stem cells is known, there are no markers for these cells. This study tested the
Junli Yan et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(6), 1841-1846 (2007-02-01)
Tight regulation of p53 is essential for maintaining normal cell growth. Here we report that BLIMP1 acts in an autoregulatory feedback loop that controls p53 activity through repression of p53 transcription. p53 binds to and positively regulates BLIMP1, which encodes
Elisa Cattaneo et al.
EMBO molecular medicine, 3(6), 334-347 (2011-05-04)
Improved colonoscopy is revealing precancerous lesions that were frequently missed in the past, and ∼30% of those detected today have nonpolypoid morphologies ranging from slightly raised to depressed. To characterize these lesions molecularly, we assessed transcription of 23,768 genes in
Emad Arafa et al.
The American journal of pathology, 185(10), 2757-2767 (2015-09-08)
Oxidative damage to renal tubular epithelial cells is a fundamental pathogenic mechanism implicated in both acute kidney injury and chronic kidney diseases. Because epithelial cell survival influences the outcome of acute kidney injury and chronic kidney diseases, identifying its molecular
Hilary F Clark et al.
Genome research, 13(10), 2265-2270 (2003-09-17)
A large-scale effort, termed the Secreted Protein Discovery Initiative (SPDI), was undertaken to identify novel secreted and transmembrane proteins. In the first of several approaches, a biological signal sequence trap in yeast cells was utilized to identify cDNA clones encoding

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