SAB2500547

Anti-ITGAM antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-α-M (complement component 3 receptor 3 subunit), Anti-CD11B, Anti-CR3A, Anti-Integrin, Anti-MAC-1
• MDL number: MFCD00240630
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: goat
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): ELISA: suitable; immunofluorescence: suitable; immunohistochemistry: suitable
• UniProt accession no.: P11215
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... ITGAM(3684)

Description

General description

Integrin α M (ITGAM) is also called as cluster of differentiation 11b (CD11b) or intercellular adhesion molecule-1 (ICAM-1). It is expressed on monocytes/macrophages, natural killer cells, neutrophils and a subset of B-and T-lymphocytes. ITGAM gene is located on human chromosome 16p11.

Immunogen

Peptide with sequence C-RNDGEDSYRTQ from the internal region of the protein sequence according to NP_000623.2 .

Biochem/physiol Actions

Integrin α M (ITGAM) is involved in cell activation, chemotaxis, cytotoxicity and phagocytosis. It modulates the interaction of leukemic cells with microenvironment by binding inactivated complement component 3b (iC3b), intercellular adhesion molecule (ICAM), fibrinogen, beta-glukanes, coagulation factor X etc. ITGAM is considered as a marker for myeloid-derived suppressor cells that participates in restraining antitumor immunity of the host and inducing the enlargement and drug-resistance of hematological malignant cells. D11b integrin contributes to ICAM-1-dependent AIDP patient mononuclear leukocyte adhesion.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable