P6656

Promazine hydrochloride

• Synonym(s): 10-(3-Dimethylaminopropyl)phenothiazine hydrochloride
• Linear Formula: C₁₇H₂₀N₂S · HCl
• CAS Number: 53-60-1
• Molecular Weight: 320.88
• Beilstein: 3753230
• EC Number: 200-179-7
• MDL number: MFCD00058535
• UNSPSC Code: 41116107
• PubChem Substance ID: 24278645
• NACRES: NA.77

Properties

• form: solid
• originator: Baxter
• storage temp.: 2-8°C
• SMILES string: Cl[H].CN(C)CCCN1c2ccccc2Sc3ccccc13
• InChI: 1S/C17H20N2S.ClH/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19;/h3-6,8-11H,7,12-13H2,1-2H3;1H
• InChI key: JIVSXRLRGOICGA-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356)

Description

General description

Promazine hydrochloride (PMZ) belongs to the phenothiazine drug family. Promazine is a D2 dopamine receptor antagonist and has antipsychotic and anticholinergic functionality. It is used for pain management and is also used for treating hypersensitivity reactions.

Application

Promazine hydrochloride has been used in conductivity and surface tension measurements and for testing inhibition of feline coronavirus (FCoV) in Felis catus whole fetus-4 (fcwf-4) cells.

Biochem/physiol Actions

D₂ dopamine receptor antagonist; phenothiazine antipsychotic.

Features and Benefits

This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H317
• Precautionary Statements: P280 - P301 + P312 + P330 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves