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P1494

Sigma-Aldrich

Monoclonal Anti-PMCA4 antibody produced in mouse

~1 mg/mL, clone JA9, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-Plasma Membrane Calcium ATPase 4

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About This Item

MDL number:
MFCD03097151
UNSPSC Code:
12352203
NACRES:
NA.44

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

JA9, monoclonal

form

buffered aqueous solution

species reactivity

human, rat

concentration

~1 mg/mL

technique(s)

immunohistochemistry: suitable
indirect ELISA: 1:15,000 using human or rat tissue
western blot: 1:1,000 using human or rat tissue

isotype

IgG1

UniProt accession no.

P23634

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ATP2B4(493)

Immunogen

purified human erythrocyte PMCA.

Physical form

Solution in phosphate buffered saline containing 1 mg/ml bovine serum albumin and 0.05 % sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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E Carafoli
Basic research in cardiology, 92 Suppl 1, 59-61 (1997-01-01)
The plasma membrane Ca-pump (134 kDa) is stimulated by calmodulin and by other treatments (exposure to acidic phospholipids, treatments with proteases, phosphorylation by protein kinases A or C, self-association to form oligomers). It is the product of four genes (in
T P Stauffer et al.
The Journal of biological chemistry, 270(20), 12184-12190 (1995-05-19)
Antibodies against the four isoforms of the human plasma membrane Ca(2+)-ATPase (PMCA) were raised using an N-terminal sequence of the pump as epitope. The antibodies against PMCA isoforms 1, 2, and 3 were not species-specific, e.g. they also recognized the
Karolina Varga et al.
Cell calcium, 55(2), 78-92 (2014-01-21)
The expression of the plasma membrane Ca2+ ATPase (PMCA) isoforms is altered in several types of cancer cells suggesting that they are involved in cancer progression. In this study we induced differentiation of MCF-7 breast cancer cells by histone deacetylase
Randa Naffa et al.
Cells, 9(5) (2020-05-18)
Metastatic melanoma is the most aggressive type of skin cancer. Previously, we identified the plasma membrane Ca2+ pump isoform 4b (PMCA4b or ATP2B4) as a putative metastasis suppressor in BRAF mutant melanoma cells. Metastasis suppressors are often downregulated in cancer
Ling Wang et al.
PloS one, 10(4), e0122932-e0122932 (2015-04-24)
An increased risk for developing essential hypertension, stroke and diabetes is associated with single nucleotide gene polymorphisms in renalase, a newly described secreted flavoprotein with oxidoreductase activity. Gene deletion causes hypertension, and aggravates acute ischemic kidney (AKI) and cardiac injury.

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