L8783

α-Lactose monohydrate

≥99% total lactose basis (GC), BioXtra

• Synonym(s): β-D-Gal-(1→4)-α-D-Glc, 4-O-β-D-Galactopyranosyl-α-D-glucose, Milk sugar
• Empirical Formula (Hill Notation): C₁₂H₂₂O₁₁ · H₂O
• CAS Number: 5989-81-1
• Molecular Weight: 360.31
• MDL number: MFCD00150747
• UNSPSC Code: 12352201
• PubChem Substance ID: 57654339
• NACRES: NA.25

Properties

• biological source: bovine milk
• Quality Level: 200
• product line: BioXtra
• Assay: ≥99% total lactose basis (GC)
• form: powder
• impurities: ≤0.01% Phosphorus (P); ≤0.1% Insoluble matter
• ign. residue: ≤0.1%
• color: white to off-white
• mp: 219 °C ((426 °F ))
• solubility: H₂O: 1 M, clear, colorless
• anion traces: chloride (Cl^-): ≤0.05%; sulfate (SO₄^2-): ≤0.05%
• cation traces: Al: ≤0.0005%; Ca: ≤0.005%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.02%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.005%; Pb: ≤0.001%; Zn: ≤0.0005%
• SMILES string: [H]O[H].OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
• InChI: 1S/C12H22O11.H2O/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17;/h3-20H,1-2H2;1H2/t3-,4-,5+,6+,7-,8-,9-,10-,11+,12+;/m1./s1
• InChI key: WSVLPVUVIUVCRA-KPKNDVKVSA-N

Description

Application

• Insights into the potential of rheological measurements in development of dry powder inhalation formulations.: This article investigates rheological properties and their implications in the development of inhalation formulas where a-Lactose monohydrate plays a crucial role (Almansour et al., 2022).


• Spray-Congealing and Wet-Sieving as Alternative Processes for Engineering of Inhalation Carrier Particles: Comparison of Surface Properties, Blending and In Vitro Performance.: The study provides a comparative analysis of spray-congealing and wet-sieving processes in engineering carrier particles for inhalation, utilizing a-Lactose monohydrate (Pinto et al., 2021).


• Conversion of a-lactose monohydrate to anhydrous form with superior tabletability by twin-screw extrusion at elevated temperature.: Discusses a method for converting a-Lactose monohydrate to a more compressible anhydrous form, enhancing its application in tablet manufacturing (Batra et al., 2020).

Biochem/physiol Actions

alpha-Lactose is the primary sugar present in milk and the main energy source to a newborn mammalian through its mother′s milk. It is digested by the intestinal lactase (EC 3.2.1.108), an enzyme expressed in newborns. The enzyme′s activity declines following weaning which can lead to lactose intolerance in adult mammals.

Other Notes

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves