L0419
Anti-LAMP1−Cy3™ antibody produced in rabbit
1-2 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-CD107a, Anti-LAMPA, Anti-LGP120, Anti-Lysosomal-associated membrane protein 1
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About This Item
Recommended Products
biological source
rabbit
Quality Level
conjugate
CY3 conjugate
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human, rat
concentration
1-2 mg/mL
technique(s)
direct immunofluorescence: 1-2 μg/mL using human HeLa cells, rat NRK cells and mouse 3T3 cells
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... LAMP1(3916)
mouse ... Lamp1(16783)
rat ... Lamp1(25328)
General description
Lysosomal-associated membrane protein 1 (LAMP1), also termed LGP120, is a heavily glycosylated lysosomal membrane protein with a molecular mass of 120 kDa. It consists of a 40 kDa core polypeptide with O-linked and 18 asparagine-linked oligosaccharide side chains. LAMP1 protein contains a leader sequence, a large intralumenal region consisting of 2 homologous domains separated by a hinge region rich in proline and serine, a 24-amino acid transmembrane region, and a short cytoplasmic tail containing the lysosomal membrane targeting signal.
The gene LAMP1 (lysosomal-associated membrane protein 1) encodes a type I transmembrane protein that has a short cytoplasmic tail containing a lysosome-targeting signal of GYQTI(382)-COOH. The gene is mapped to human chromosome 13q34.
Application
Anti-LAMP1-Cy3™ antibody produced in rabbit has been used in immunofluorescence.
Biochem/physiol Actions
The gene LAMP1 (lysosomal associated membrane protein 1) encodes a membrane glycoprotein that functions as an intracellular receptor. It is found to be expressed in the cytoplasm of several types of tumor cells and may be involved in tumor invasion. Lamp1 is crucial for perforin trafficking to the lytic granules and motility of these lytic granules. Its knockdown leads to inhibition of cytotoxicity of human natural killer cells.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Legal Information
Cy3 is a trademark of Cytiva
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Product No.
Description
Pricing
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Expression of the lysosomal-associated membrane protein-1 (LAMP-1) in astrocytomas
Jensen SS, et al.
International Journal of Clinical and Experimental Pathology, 6(7), 1294-1294 (2013)
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Three-dimensional invasion of macrophages is mediated by cysteine cathepsins in protrusive podosomes.
Jevnikar Z, et.al.
European Journal of Immunology, 42, 3429-3441 (2012)
Zala Jevnikar et al.
European journal of immunology, 42(12), 3429-3441 (2012-09-29)
Podosomes, specialized actin-rich structures in macrophages (Mfs), degrade the extra-cellular matrix (ECM) and are involved in cell migration. On two-dimensional (2D) surfaces Mfs form spot-like podosomes at the ventral cell surface that develop into protrusive structures in a three-dimensional (3D)
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