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G8769

Sigma-Aldrich

D-(+)-Glucose solution

45% in H2O, sterile-filtered, BioXtra, suitable for cell culture

Synonym(s):

D-Glucopyranose

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About This Item

Empirical Formula (Hill Notation):
C6H12O6
CAS Number:
50-99-7
Molecular Weight:
180.16
Beilstein:
1281608
EC Number:
200-075-1
MDL number:
MFCD00063774
UNSPSC Code:
12352201
PubChem Substance ID:
24895351
NACRES:
NA.75

sterility

sterile-filtered

Quality Level

200

product line

BioXtra

form

solution

concentration

45% in H2O

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

SMILES string

OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1

InChI key

WQZGKKKJIJFFOK-DVKNGEFBSA-N

Gene Information

human ... PYGM(5837)

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General description

Glucose is the energy currency essential for physiological processes in the living cells. It serves as a precursor for glycoproteins, glycolipids and glycosaminoglycans.

Application

D-(+)-Glucose solution has been used as a medium supplement:
  • in Dulbecco′s Modified Eagle Medium (DMEM) for culturing Flp-In  293 cells
  • in dissection medium for coronal slices from rat brain
  • in neurobasal medium for culturing hippocampi cells

Provides the primary energy source for cell metabolism.

Biochem/physiol Actions

Glucose is a crucial component for the growth and maintenance of mammalian cells in in vitro conditions and is essential for productivity and quality. Its high metabolic turnover favors osteoclast differentiation. The levels of glucose modulate the migration and growth of tumor cells. HeLa cells display high mobility at low glucose levels.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Investigation of the Influence of Glucose Concentration on Cancer Cells by Using a Microfluidic Gradient Generator without the Induction of Large Shear Stress
Ishida T, et al.
Micromachines, 7(9), 155-155 (2016)
Protein kinase C activation causes neurite retraction via cyclin D 1 and p60-katanin increase in rat hippocampal neurons
Korulu S, et al.
The European Journal of Neuroscience, 37(10), 1610-1619 (2013)
An ex vivo method for evaluating the biocompatibility of neural electrodes in rat brain slice cultures
Koeneman BA, et al.
Journal of Neuroscience Methods, 137(2), 257-263 (2004)
Chad A Dumstorf et al.
Molecular cancer therapeutics, 9(12), 3158-3163 (2010-10-26)
Enzastaurin (LY317615.HCl) is currently in a phase III registration trial for diffuse large B-Cell lymphoma and numerous phase II clinical trials. Enzastaurin suppresses angiogenesis and induces apoptosis in multiple human tumor cell lines by inhibiting protein kinase C (PKC) and
High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells
Vergara M, et al.
Testing, 13(8), e0202098-e0202098 (2018)
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Articles

Insulin Signaling and Energy Homeostasis

Glucose metabolism is regulated by the opposing actions of insulin and glucagon. Insulin is released from pancreatic ß cells in response to high blood glucose levels and regulates glucose metabolism through its actions on muscle, liver, and adipose tissue.

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