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D6288

Sigma-Aldrich

6α,9α-Difluoroprednisolone 21-acetate 17-butyrate

≥98%

Synonym(s):

Difluprednate

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About This Item

Empirical Formula (Hill Notation):
C27H34F2O7
CAS Number:
23674-86-4
Molecular Weight:
508.55
EC Number:
245-815-4
MDL number:
MFCD00214273
UNSPSC Code:
12352202
PubChem Substance ID:
24894018
NACRES:
NA.77

sterility

non-sterile

Quality Level

200

Assay

≥98%

form

powder

solubility

chloroform: 50 mg/mL, clear, colorless

shipped in

ambient

storage temp.

2-8°C

SMILES string

CCCC(=O)O[C@@]1(CC[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)COC(C)=O

InChI

1S/C27H34F2O7/c1-5-6-23(34)36-26(22(33)14-35-15(2)30)10-8-17-18-12-20(28)19-11-16(31)7-9-24(19,3)27(18,29)21(32)13-25(17,26)4/h7,9,11,17-18,20-21,32H,5-6,8,10,12-14H2,1-4H3/t17-,18-,20-,21-,24-,25-,26-,27-/m0/s1

InChI key

WYQPLTPSGFELIB-JTQPXKBDSA-N

Gene Information

human ... NR3C1(2908)

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Atsuo Tanimoto et al.
Experimental dermatology, 27(1), 22-29 (2017-04-20)
Janus kinases (JAKs) are required for several inflammatory cytokine signalling pathways and are implicated in the pathogenesis of chronic dermatitis, including atopic dermatitis and psoriasis. JAK inhibitors are therefore promising therapeutic candidates for chronic dermatitis. In this study, we evaluated
Eric J Sigler et al.
Retina (Philadelphia, Pa.), 34(2), 237-246 (2013-07-25)
To describe the clinical and histopathologic characteristics of inflammatory deposits occurring within intermediate duration postoperative perfluoro-n-octane (PFO) for inferior retinal detachment repair. Prospective interventional case series of consecutive patients with inferior retinal detachment treated with intermediate duration postoperative vitreous cavity
Shin-ichi Yasueda et al.
Journal of pharmaceutical and biomedical analysis, 30(6), 1735-1742 (2002-12-18)
A specific and sensitive method for the determination for difluprednate (DFBA) and its metabolite (deacetylated DFBA, DFB) in aqueous humor was developed. DFBA and DFB were initially absorbed on a Pinkerton-type column, then analyzed by high-performance liquid chromatography using a
Yixuan Dong et al.
Journal of pharmaceutical sciences, 108(6), 2002-2011 (2019-01-15)
Pharmaceutical emulsions contain multiple components, such as micellar, aqueous, and oil phases, leading to complex drug transfer and equilibrium phenomena. These complex components present challenges for the bioequivalence assessment of the drug products. The objective of the study was to
Mahmoud Tawfik KhalafAllah et al.
BMJ open, 9(11), e026752-e026752 (2019-11-05)
Topical steroids are the cornerstone in controlling the inflammation after cataract surgery. Prednisolone acetate and difluprednate are the two main products for this purpose. However, it is unclear which one should be used in terms of effectiveness and safety. Systematic
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