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COO/COA

N^G,N^G-Dimethylarginine dihydrochloride

Name: NG,NG-Dimethylarginine dihydrochloride
Brand: SIGMA

Synonym(s):

asym-Dimethylarginine, ADMA

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₈N₄O₂ · 2HCl

CAS Number:

220805-22-1

Molecular Weight:

275.18

MDL number:

MFCD00270857

UNSPSC Code:

12352209

PubChem Substance ID:

24278027

NACRES:

NA.77

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D0627

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D0260

N⁶,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt

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D0390

N^G,N^G′-Dimethyl-L-arginine di(p-hydroxyazobenzene-p′-sulfonate) salt

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311204

N^G,N^G′-Dimethyl-L-arginine, Dihydrochloride

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SMB00938

Dimethyl-L-arginine

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H3149

Heparin sodium salt from porcine intestinal mucosa

Sigma-Aldrich

R2625

Retinoic acid

Sigma-Aldrich

H3393

Heparin sodium salt from porcine intestinal mucosa

Assay

≥98% (TLC)

Quality Level

200

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O

InChI

1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1

InChI key

SYLNVYJOPZWPJI-ILKKLZGPSA-N

Gene Information

human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)

General description

N^G,N^G-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).

Application

N^G,N^G- Dimethylarginine dihydrochloride has been used:

to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
as a standard for measuring L-arginine and dimethylarginines
to study its effects on hepatic deterioration

Biochem/physiol Actions

Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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SpringerPlus, 3, 98-98 (2014-03-07)

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Cardiovascular diabetology, 16(1), 146-146 (2017-11-11)

The cardiovascular benefits of statins have been proven, but their effect on circulation in small vessels has not been examined fully. We investigated the effect of 20 mg rosuvastatin on biomarkers, including paraoxonase-1 (PON-1) and asymmetric dimethylarginine (ADMA), and on microvascular

Asymmetric dimethylarginine serum levels are associated with early mortality after allogeneic stem cell transplantation.

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Increasing evidence suggests that endothelial cell distress is associated with mortality after allogeneic stem cell transplantation and acute graft-versus-host disease. Asymmetric dimethylarginine is an endogenous nitric oxide synthase inhibitor that induces endothelial cell dysfunction. We analyzed the impact of pre-transplant

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Asymmetric dimethylarginine predicts the risk of contrast-induced acute kidney injury in patients undergoing cardiac catheterization.

Tse-Min Lu et al.

Atherosclerosis, 254, 161-166 (2016-10-17)

Decreased nitric oxide (NO) bioavailability and increased oxidative stress may be involved in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). The relationship between asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, and CI-AKI is unknown. We measured plasma ADMA

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Key Documents

N^G,N^G-Dimethylarginine dihydrochloride

About This Item

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Properties

Assay

Quality Level

form

solubility

storage temp.

SMILES string

InChI

InChI key

Gene Information

Description

General description

Application

Biochem/physiol Actions

Safety Information

Storage Class Code

WGK

Flash Point(F)

Flash Point(C)

Personal Protective Equipment

Documentation

Certificates of Analysis (COA)

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