30432

Dansylcadaverine

suitable for fluorescence, BioReagent, ≥99.0% (HPLC)

• Synonym(s): N-(5-Amino­pentyl)-5-di­methyl­amino­naphtha­lene-1-sulfon­amide, N-(Dimethyl­amino­naphtha­lene­sulfonyl)-1,5-pentane­diamine, Monodansyl cadaverine
• Empirical Formula (Hill Notation): C₁₇H₂₅N₃O₂S
• CAS Number: 10121-91-2
• Molecular Weight: 335.46
• Beilstein: 2951070
• EC Number: 233-326-9
• MDL number: MFCD00042704
• UNSPSC Code: 12352108
• PubChem Substance ID: 57648439
• NACRES: NA.32

Properties

• product line: BioReagent
• Assay: ≥99.0% (HPLC)
• mp: 137-140 °C
• fluorescence: λ_ex 335 nm; λ_em 518 nm in methanol; λ_ex 338 nm; λ_em 500 nm (Reaction product)
• suitability: suitable for fluorescence
• storage temp.: −20°C
• SMILES string: CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN
• InChI: 1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
• InChI key: MLEBFEHOJICQQS-UHFFFAOYSA-N

Description

Application

Dansylcadaverine (MDC), an autofluorescent dye, is used to monitor autophagy. MDC accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

Biochem/physiol Actions

Inhibitor of the fibrin-stabilizing fator; Inhibitor of epidermal growth factor (EGF) internalization; Fluorescent substrate for the assay of transamidating enzymes.

The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

air sensitive, handled under inert gas

Other Notes

Solubility of dansylcadaverine is tested in methanol (10 mg/mL). It has also been reported that dansylcadaverine is soluble in DMSO and acetic acid.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves