SMB01325

Albendazole sulfoxide

≥97% (HPLC)

• Synonym(s): Ricobendazole, Albendazole oxide, Albendazole sulfoxide, Methyl [5-(propane-1-sulfinyl)-1H-benzoimidazol-2-yl]-carbamate
• Empirical Formula (Hill Notation): C₁₂H₁₅N₃O₃S
• CAS Number: 54029-12-8
• Molecular Weight: 281.33
• Beilstein: 677664
• MDL number: MFCD00797922
• UNSPSC Code: 12352119
• NACRES: NA.77

Properties

• description: Modulation and Signaling
• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: solid
• color: white to beige
• suitability: HPTLC
• storage temp.: 2-8°C
• SMILES string: CCCS(=O)c1ccc2[nH]c(NC(=O)OC)nc2c1
• InChI: 1S/C12H15N3O3S/c1-3-6-19(17)8-4-5-9-10(7-8)14-11(13-9)15-12(16)18-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
• InChI key: VXTGHWHFYNYFFV-UHFFFAOYSA-N

Description

General description

Albendazole sulfoxide is a blood-brain barrier main metabolite of anti-parasitic agent albendazole that acts as a antihelminthic. It binds to colchicine binding site of β-tubulin and prevents polymerization. Albendazole sulfoxide exhibits greater affinity to parasitic β-tubulin than to mammalian.

Application

Metabolomics research

Biochem/physiol Actions

Ricobendazole is a key metabolite of albendazole and acts as an anthelmintic. It has been shown to induce apoptosis in human cancer cell line HT-29, possibly by arresting cell cycle at the G₂/M phase.

Other Notes

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Safety Information

• Pictograms: GHS08,GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H317,H361d,H373,H410
• Precautionary Statements: P202 - P260 - P273 - P280 - P302 + P352 - P308 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1 - STOT RE 2 Oral
• Target Organs: Adrenal gland,spleen,male reproductive organs,Blood
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable