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42754

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Ginsenoside Rk1

analytical standard

Synonym(s):

(3β, 12β)-12-Hydroxydammara-20,24-dien-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside

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About This Item

Empirical Formula (Hill Notation):
C42H70O12
CAS Number:
Molecular Weight:
767.00
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

Assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

format

neat

storage temp.

2-8°C

Inchi Code

1S/C42H70O12/c1-21(2)10-9-11-22(3)23-12-16-42(8)30(23)24(45)18-28-40(6)15-14-29(39(4,5)27(40)13-17-41(28,42)7)53-38-36(34(49)32(47)26(20-44)52-38)54-37-35(50)33(48)31(46)25(19-43)51-37/h10,23-38,43-50H,3,9,11-20H2,1-2,4-8H3/t23-,24-,25?,26?,27+,28-,29+,30+,31-,32-,33?,34?,35?,36?,37+,38+,40+,41-,42-/m1/s1

InChI key

KWDWBAISZWOAHD-NPRXNXDWSA-N

SMILES string

CC1(C)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)CC[C@@]4(C)[C@@]1([H])CC[C@]5(C)[C@]4([H])C[C@@H](O)[C@@]6([H])[C@@]5(C)CC[C@@]6(C(CCC=C(C)C)=C)[H]

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General description

Ginsenoside Rk1 is the major bioactive component isolated from heat-processed Panax ginseng Meyer (ginseng) plants. It is a monomeric compound that has been reported to exhibit anti-inflammatory, anti-allergic, and anti-tumor properties and is utilized for the treatment of cancer and diabetes mellitus.

Application

Ginsenoside Rk1 may be used as an analytical reference standard for the determination of the analyte in Panax ginseng preparations and Chinese medicine formula Sheng-Mai San (SMS) and rat plasma samples (post administration of SMS) by chromatography techniques.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Anti-tumor activity of the ginsenoside Rk1 in human hepatocellular carcinoma cells through inhibition of telomerase activity and induction of apoptosis
Kim YJ, et al.
Biological & Pharmaceutical Bulletin, 31(5), 826-830 (2008)
Simultaneous determination of 30 ginsenosides in Panax ginseng preparations using ultra performance liquid chromatography
Park HW, et al.
Journal of ginseng research, 37(4), 457-457 (2013)
Identification of multiple constituents in the traditional Chinese medicine formula Sheng-Mai San and rat plasma after oral administration by HPLC-DAD-MS/MS
Wang YH, etal.
Journal of Pharmaceutical and Biomedical Analysis, 54(5), 1110-1127 (2011)
Simultaneous quantification of 14 ginsenosides in Panax ginseng CA Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control.
Kim NS, et al.
Journal of Pharmaceutical and Biomedical Analysis, 45(1), 164-170 (2007)

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