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Key Documents

AB5986P

Sigma-Aldrich

Anti-Tyrosine Hydroxylase Antibody

Chemicon®, from rabbit

Synonym(s):

TH, Tyrosine Monooxygenase

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable

NCBI accession no.

NM_000360.3
NM_199292.2
NM_199293.2

UniProt accession no.

P07101

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... TH(7054)

Specificity

Tyrosine Hydroxylase. Immunohistochemical distribution throughout the brain shows that staining is restricted to those neurons known to contain the enzyme. The antibody has proven useful in staining catecholaminergic neurons. AB5986 stains these neurons intensely, including dendritic processes and fine nerve terminals.

Immunogen

Synthetic peptide corresponding to amino acids 32-47 of rat Tyrosine Hydroxylase.

Application

Detect Tyrosine Hydroxylase using this Anti-Tyrosine Hydroxylase Antibody validated for use in IH.
Immunohistochemistry: 0.5-1.0 μg/mL.

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Neuronal & Glial Markers

Physical form

Affinity purified immunoglobulin.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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D Rotllant et al.
Neuroscience, 168(3), 691-705 (2010-04-22)
Previous studies have shown that amphetamine (AMPH) markedly activates dopaminergic projection areas, together with some important limbic nuclei. However, a global picture of the brain areas activated is lacking and the contribution of the dose of the drug and individual
Immunohistochemical studies on phosphorylation of tyrosine hydroxylase in central catecholamine neurons using site- and phosphorylation state-specific antibodies.
Xu, Z Q, et al.
Neuroscience, 82, 727-738 (1998)
Stephanie J Cragg et al.
The European journal of neuroscience, 20(7), 1788-1802 (2004-09-24)
The direct modulation of subthalamic nucleus (STN) neurons by dopamine (DA) neurons of the substantia nigra (SN) is controversial owing to the thick caliber and low density of DA axons in the STN. The abnormal activity of the STN in
Antibodies to a segment of tyrosine hydroxylase phosphorylated at serine 40.
Goldstein, M, et al.
Journal of Neurochemistry, 64, 2281-2287 (1995)
Antibodies to a synthetic peptide corresponding to a Ser-40-containing segment of tyrosine hydroxylase: activation and immunohistochemical localization of tyrosine hydroxylase.
Lee, K Y, et al.
Journal of Neurochemistry, 53, 1238-1244 (1989)
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