V-020

(±)−α−Tocopherol (Vitamin E) solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Synonym(s): (±)-α-Tocopherol, DL-all-rac-α-Tocopherol, Vitamin E
• Empirical Formula (Hill Notation): C₂₉H₅₀O₂
• CAS Number: 10191-41-0
• Molecular Weight: 430.71
• Beilstein: 94012
• EC Number: 200-659-6
• MDL number: MFCD00006848
• UNSPSC Code: 41116107
• PubChem Substance ID: 329828963
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1.0 mg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• density: 0.950 g/mL at 20 °C (lit.)
• application(s): clinical testing; clinical testing
• format: single component solution
• storage temp.: −70°C
• SMILES string: CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1
• InChI: 1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
• InChI key: GVJHHUAWPYXKBD-UHFFFAOYSA-N

Description

General description

α-Tocopherol is a form of fat-soluble vitamin E and shows anti-oxidant, anti-inflammatory, anti-cell proliferative, and anti-cancer properties. Often the result of poor nutrition or low absorption of dietary fat, its deficiency is monitored in patient serum samples by LC-MS/MS or HPLC.

Application

This Certified Spiking Solution^® is suitable for use in a variety of testing applications from diagnostic testing of Vitamin E deficiency to quality control testing of tocopherol-based dietary supplements or pharmaceutical preparations by HPLC or LC-MS/MS.The certified reference solution (CRM) in solution can also be used as follows:

• Simultaneous determination of vitamin A and all four tocopherol isomers in human serum samples by ultra-high performance liquid chromatography (UHPLC) combined with fluorescence detection following their liquid-liquid extraction (LLE)
• Multi-residue analysis of vitamin B (B₁, B₂, B₅, and B₉), and vitamin E (α-tocopherol, β-tocopherol, α-tocotrienol, and β-tocotrienol) in grass and grain samples of four different wheat varieties by liquid chromatography-electrospray ionization/multistage mass spectrometry (LC-ESI-MS/MS)
• Separation and estimation of four tocopherols and four tocotrienols in pecan nut cultivar samples using non-aqueous reversed-phase high-performance liquid chromatography (NARP-HPLC) coupled with atmospheric pressure chemical ionization-tandem mass spectrometric (APCI-MS/MS) detection
• Analysis of different cold pressed oil samples to detect and quantify eight tocol- homologs using a chemometrically-assisted optimized high-performance liquid chromatography (HPLC) with fluorescence detection (FLD) based method
• High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) based combined analysis of retinol, α‐tocopherol, 25‐hydroxyvitamin D₂, and 25‐hydroxyvitamin in plasma samples of cardiovascular patients

Features and Benefits

• Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
• Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
• Rigorously tested through real-time stability studies to ensure accuracy and shelf life
• Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
• Flame sealed under argon into ampoules for long-term shelf life
• Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup