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857127P

Avanti

17:0 Lyso PA

1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt), powder

Synonym(s):

heptadecanoyl lysophosphatidic acid; 1-heptadecanoyl-sn-glycero-3-phosphate (sodium salt); PA(17:0/0:0); 17:0 LPA; 110679

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About This Item

Empirical Formula (Hill Notation):
C20H40O7PNa
CAS Number:
799268-66-9
Molecular Weight:
446.49
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)

form

powder

packaging

pkg of 1 × 25 mg (857127P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 857127P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

General description

Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA), a bioactive phospholipid is seen at a low level in plasma (~100 nM). It is usually formed during the synthesis of phospholipid of cell membranes. It is produced by various cells like, activated platelets, epithelial cells, leukocytes, neuronal cells and tumor cells.

Application

17:0 Lyso PA is suitable to use as an internal standard:
  • for mass spectrometric determination of lysophosphatidic acid molecular species in mouse peritoneal macrophages
  • in the quantification of the lipid species released from extended synaptotagmin 2 (E-SYT2) expressed in mammalian cells by liquid chromatography with tandem mass spectrometry (LC-MS/MS)
  • for the extraction of lipids from brain homogenate
  • to extract lipids from the stomach washing solution for the determination of lysophosphatidic acid in a mouse stomach fluid

Biochem/physiol Actions

Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA) modulates cell motility, proliferation, invasion, survival and production of growth factors via G protein-coupled receptor (GPCR).

Packaging

5 mL Amber Glass Screw Cap Vial (857127P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2\beta (group VIA phospholipase A2)
Ashley JW, et al.
The Journal of Biological Chemistry, 291(44), 23268-23281 (2016)
Lysophosphatidic acid in medicinal herbs enhances prostaglandin E2 and protects against indomethacin-induced gastric cell damage in vivo and in vitro
Afroz S, et al.
Prostaglandins & other lipid mediators, 135, 36-44 (2018)
Comprehensive phospholipid and sphingomyelin profiling of different brain regions in mouse model of anxiety disorder using online two-dimensional (HILIC/RP)-LC/MS method
Berkecz R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 149, 308- 317 (2018)
Lysophosphatidic acid triggers apoptosis in HeLa cells through the upregulation of tumor necrosis factor receptor superfamily member 21
Dong Y, et al.
Mediators of Inflammation, 2017 (2017)
Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer
Schauder CM, et al.
Nature, 510(7506), 552-552 (2014)
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