900915
N-Azidoacetylgalactosamine-tetraacylated
Synonym(s):
Ac4GalNAz
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About This Item
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form
powder or crystals
Quality Level
reaction suitability
reaction type: click chemistry
storage temp.
−20°C
Application
N-Azidoacetylgalactosamine-tetraacylated (Ac4GalNAz) provides the first part of a simple and robust two-step technique that helps identify and characterize cell surface sialic acid-containing glycoproteins. The azide-modified protein can be detected by reaction with alkynes. For example alkynes labeled with a fluorescent probe or a biotin can be used. The acetyl groups increase cell permeability and allow the unnatural sugars to easily pass through the cell membrane. Carboxyesterases remove the acetyl groups once the monosaccharide is in the cell.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Monitoring protein O-linked β-N-acetylglucosamine status via metabolic labeling and copper-free click chemistry.
Analytical Biochemistry, 464, 70-72 (2014)
Probing glycosyltransferase activities with the Staudinger ligation.
Journal of the American Chemical Society, 126(1), 6-7 (2004)
A chemoenzymatic approach toward the preparation of site-specific antibody?drug conjugates.
Tetrahedron Letters, 56(23), 3172-3175 (2015)
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