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Key Documents

747386

Sigma-Aldrich

Poly(L-lactide), thiol terminated

average Mn 2,500, PDI ≤1.2

Synonym(s):

mercapto PLA, mercapto PLLA, thioPLA

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About This Item

Linear Formula:
H(C3H4O2)nOC2H4SH
UNSPSC Code:
12162002
NACRES:
NA.23

form

solid

optical activity

[α]22/D -138°, c = 0.5% in chloroform

mol wt

average Mn 2,500

transition temp

Tm 127-137 °C

PDI

≤1.2

storage temp.

2-8°C

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Articles

MALDI-TOF MS is a tool for confirming end group identity & transformations, verifying successful & complete conjugation. Functionalized polymers enable a quick & efficient route for synthesis of various polymer conjugates for many applications if apt end group is present.

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

The world of commercial biomaterials has stagnated over the past 30 years as few materials have successfully transitioned from the bench to clinical use. Synthetic aliphatic polyesters have continued to dominate the field of resorbable biomaterials due to their long history and track record of approval with the U.S. Food and Drug Administration (FDA).

Wide range of functional polymers for biomedical applications have been synthesized and structurally characterized. Several classes of polymers including biodegradable polymers, hydrophilic & amphiphilic polymers, and stimuli responsive polymers have been prepared using controlled and directed functionalization via "living" polymerization such as RAFT, ionic and ring opening polymerization. Selected polymers have been studied for their structure-properties relationship. "

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