707066
DCA Deblock (0.36M dichloroacetic acid in toluene)
Synonym(s):
DCA Deblock, DEBLOCK (0.36M dichloroacetic acid in toluene)
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About This Item
Empirical Formula (Hill Notation):
C2H2Cl2O2
CAS Number:
Molecular Weight:
128.94
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
form
liquid
Quality Level
concentration
≤100 ppm in H2O
bp
110-111 °C
density
0.884 g/mL at 25 °C
SMILES string
OC(=O)C(Cl)Cl
InChI
1S/C2H2Cl2O2/c3-1(4)2(5)6/h1H,(H,5,6)
InChI key
JXTHNDFMNIQAHM-UHFFFAOYSA-N
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General description
Deblock solution, containing dichloroacetic acid (DCA) in dichloromethane or Toluene, removes the dimethoxytrityl (DMT) protecting the group from the 5′ hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, prior to the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′ hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction.
Application
DCA Deblock (0.36M dichloroacetic acid in toluene) is suitable for the removal of 4,4Adimethoxytrityl (DMTr) protecting groups for the synthesis of antisense oligonucleotides in high yield and purity.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 3 - Asp. Tox. 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Lact. - Repr. 1B - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3
Target Organs
Central nervous system
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
41.0 °F
Flash Point(C)
5 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Jae Mo Park et al.
Neuro-oncology, 15(4), 433-441 (2013-01-19)
The metabolic phenotype that derives disproportionate energy via glycolysis in solid tumors, including glioma, leads to elevated lactate labeling in metabolic imaging using hyperpolarized [1-(13)C]pyruvate. Although the pyruvate dehydrogenase (PDH)-mediated flux from pyruvate to acetyl coenzyme A can be indirectly
Toshimitsu Ohashi et al.
International journal of cancer, 133(5), 1107-1118 (2013-02-20)
The activation of oncogenic signaling pathways induces the reprogramming of glucose metabolism in tumor cells and increases lactic acid secretion into the tumor microenvironment. This is a well-known characteristic of tumor cells, termed the Warburg effect, and is a candidate
Yong Won Choi et al.
Cancer letters, 346(2), 300-308 (2014-02-01)
To investigate sensitization of metformin-cytotoxicity, cancer cells were treated with dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase (PDK). Metformin-cytotoxicity was mainly dependent on glucose availability and reducing power generated by pentose phosphate pathway, whereas DCA cotreatment enhanced metformin-cytotoxicity via
Ernesto Miquel et al.
PloS one, 7(4), e34776-e34776 (2012-04-18)
Mitochondrial dysfunction is one of the pathogenic mechanisms that lead to neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). Astrocytes expressing the ALS-linked SOD1(G93A) mutation display a decreased mitochondrial respiratory capacity associated to phenotypic changes that cause them to induce motor neuron
Haihua Xiao et al.
Chemical communications (Cambridge, England), 48(87), 10730-10732 (2012-09-27)
A multifunctional hybrid platinum(IV) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crosslinking drug cisplatin, was synthesized and tethered to a carrier polymer to further self-assemble into micelles for intracellular delivery.
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