561665

3-Fluorophenylmagnesium bromide solution

0.5 M in THF

• Linear Formula: FC₆H₄MgBr
• CAS Number: 17318-03-5
• Molecular Weight: 199.30
• MDL number: MFCD00672007
• UNSPSC Code: 12352103
• PubChem Substance ID: 24879960
• NACRES: NA.22

Properties

• reaction suitability: reaction type: Grignard Reaction
• concentration: 0.5 M in THF
• bp: 65 °C
• density: 0.936 g/mL at 25 °C
• storage temp.: 2-8°C
• SMILES string: Fc1cccc([Mg]Br)c1
• InChI: 1S/C6H4F.BrH.Mg/c7-6-4-2-1-3-5-6;;/h1-2,4-5H;1H;/q;;+1/p-1
• InChI key: VFPDAAQAKDGSHQ-UHFFFAOYSA-M

Description

Application

3-Fluorophenylmagnesium bromide is a Grignard reagent that can be used in:

• The preparation of 4-substituted quinazolines by reacting with 2-methylaminobenzonitriles.
• The synthesis of radiolabeled TrkB/C-targeting kinase inhibitor for positron emission tomography (PET) imaging applications.
• Cu-catalyzed carbometalation of substituted cyclopropenes.

Legal Information

Product of Rieke^® Metals, Inc.

Rieke is a registered trademark of Rieke Metals, Inc.

Safety Information

• Pictograms: GHS02,GHS08,GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H302,H314,H335,H351
• Precautionary Statements: P210 - P260 - P280 - P305 + P351 + P338 - P370 + P378 - P403 + P235
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
• Target Organs: Respiratory system
• Supplementary Hazards: EUH014,EUH019
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 1.4 °F - closed cup
• Flash Point(C): -17 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves