540072

(R)-(−)-Epichlorohydrin

99%

• Synonym(s): (R)-(−)-2-(Chloromethyl)oxirane
• Empirical Formula (Hill Notation): C₃H₅ClO
• CAS Number: 51594-55-9
• Molecular Weight: 92.52
• Beilstein: 1420785
• EC Number: 424-280-2
• MDL number: MFCD00077759
• UNSPSC Code: 12352103
• PubChem Substance ID: 24878437
• NACRES: NA.22

Properties

• vapor density: 3.29 (vs air)
• Quality Level: 100
• vapor pressure: 10 mmHg ( 16.6 °C)
• Assay: 99%
• optical activity: [α]20/D −34°, c = 1 in methanol
• optical purity: ee: 98% (GLC)
• autoignition temp.: 772 °F
• expl. lim.: 21 %
• refractive index: n20/D 1.438 (lit.)
• bp: 114 °C (lit.)
• density: 1.180 g/mL at 20 °C (lit.)
• functional group: chloro; ether
• SMILES string: ClC[C@H]1CO1
• InChI: 1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2/t3-/m0/s1
• InChI key: BRLQWZUYTZBJKN-VKHMYHEASA-N

Description

Application

Building block for the synthesis of a key intermediate in the synthesis of stable PGI₂ analogue UT-15.

Used in the synthesis of chiral morpholines and dioxanes via a Mitsunobu diol-cyclization. Chiral building block in the enantioselective synthesis of trans-2,4-disubstituted piperidines.

Legal Information

Manufactured under license by Sterling Pharma Solutions Limited, using Jacobsen HKR technology.

Safety Information

• Pictograms: GHS02,GHS06,GHS08,GHS05
• Signal Word: Danger
• Hazard Statements: H226,H301 + H311 + H331,H314,H317,H350
• Precautionary Statements: P202 - P210 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 1B - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - Skin Sens. 1
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 89.6 °F - closed cup
• Flash Point(C): 32 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves