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532169

(R)-(−)-N-Boc-3-pyrrolidinol

Name: (<I>R</I>)-(−)-<I>N</I>-Boc-3-pyrrolidinol
Brand: ALDRICH

98%

Synonym(s):

(R)-N-tert-Butoxycarbonyl-(−)-3-pyrrolidinol

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₇NO₃

CAS Number:

109431-87-0

Molecular Weight:

187.24

MDL number:

MFCD01317838

UNSPSC Code:

12352005

PubChem Substance ID:

24877863

NACRES:

NA.22

Assay

98%

optical activity

[α]20/D −26±1, c = 1 in methanol

mp

62-65 °C (lit.)

SMILES string

CC(C)(C)OC(=O)N1CC[C@@H](O)C1

InChI

1S/C9H17NO3/c1-9(2,3)13-8(12)10-5-4-7(11)6-10/h7,11H,4-6H2,1-3H3/t7-/m1/s1

InChI key

APCBTRDHCDOPNY-SSDOTTSWSA-N

Related Categories

Catalysts

Chemistry & Biochemicals

Chiral Catalysts & Ligands

Application

Used in synthesis of ligands for the nicotinic acetylcholine receptor.

Used in the synthesis of anticoagulants.

Pictograms

GHS07,GHS09

Signal Word

Warning

Hazard Statements

H315,H319,H335,H400

Precautionary Statements

P261 - P264 - P271 - P273 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Synthesis and structure-activity relationship of novel pyridyl ethers for the nicotinic acetylcholine receptor.

J Lee et al.

Bioorganic & medicinal chemistry letters, 10(10), 1063-1066 (2000-06-08)

The preparation of novel pyridyl ethers as ligands for the nicotinic acetylcholine receptor (nAChR) is described. Variations of the ring size of the azacycle and substitution on the pyridine had dramatic effects on receptor binding affinity with IC50s at the

Design, synthesis and biological activity of amidinobicyclic compounds (derivatives of DX-9065a) as factor Xa inhibitors: SAR study of S1 and aryl binding sites.

Satoshi Komoriya et al.

Bioorganic & medicinal chemistry, 12(9), 2099-2114 (2004-04-15)

Since factor Xa (fXa) plays a pivotal role in the blood coagulation cascade, inhibition of fXa is thought to be an effective treatment for a variety of thrombotic events. (2S)-2-[4-[[(3S)-1-Acetimidoyl-3-pyrrolidinyl]oxy]phenyl]-3-(7-amidino-2-naphthyl)propanoic acid hydrochloride pentahydrate (DX-9065a) was previously found in our laboratory

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