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(S)-(−)-1,2-Diaminopropane dihydrochloride

Name: (<I>S</I>)-(−)-1,2-Diaminopropane dihydrochloride
Brand: ALDRICH

99%

Synonym(s):

(S)-(−)-Propylenediamine dihydrochloride, (S)-1,2-Propanediamine dihydrochloride

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About This Item

Linear Formula:

CH₃CH(NH₂)CH₂NH₂·2HCl

CAS Number:

19777-66-3

Molecular Weight:

147.05

Beilstein:

5740936

MDL number:

MFCD00050706

UNSPSC Code:

12352116

PubChem Substance ID:

24865810

NACRES:

NA.22

Assay

99%

optical activity

[α]22/D −4°, c = 20 in H₂O

mp

227-229 °C (lit.)

SMILES string

Cl.Cl.C[C@H](N)CN

InChI

1S/C3H10N2.2ClH/c1-3(5)2-4;;/h3H,2,4-5H2,1H3;2*1H/t3-;;/m0../s1

InChI key

AEIAMRMQKCPGJR-QTNFYWBSSA-N

Application

(S)-(-)-1,2-Diaminopropane dihydrochloride may be used in the preparation of following chiral imidazoline derivatives, which show moderate α-adrenergic blocking activity:

(S)-(-)-4-methyl-2-(1-naphthylmethyl)imidazoline hydrochloride
(S)-(-)-2-benzyl-4-methylimidazoline picrate
(S )-(-)-2-[(2,6-dichlorophenyl)imino]-4-methylimidazolidine hydrochloride

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Stereochemical studies of adrenergic drugs. Optically active derivatives of imidazolines.

Miller DD, et al.

Journal of Medicinal Chemistry, 19(12), 1382-1384 (1976)

Optically active derivatives of imidazolines: a-Adrenergic blocking properties.

Hsu FL, et al.

Journal of Medicinal Chemistry, 23(11), 1232-1235 (1980)

Chiral cyanide-bridged Mn(II)Mn(III) ferrimagnets, [Mn(II)(HL)(H2O)][Mn(III)(CN)6].2H2O (L = S- or R-1,2-diaminopropane): syntheses, structures, and magnetic behaviors.

Wakako Kaneko et al.

Journal of the American Chemical Society, 129(2), 248-249 (2007-01-11)

Conformational change of spermidine upon interaction with adenosine triphosphate in aqueous solution.

Keisuke Maruyoshi et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 15(7), 1618-1626 (2009-01-09)

Endogenous polyamines, represented by putrescine, spermidine, and spermine, are known to exert their physiological functions by interacting with polyanionic biomolecules such as DNA, RNA, adenosine triphosphate (ATP), and phospholipids. Very few examples of conformation analysis have been reported for these

Enrichment of trace amounts of copper(II) ions in water samples using octadecyl silica disks modified by a Schiff base ionophore prior to flame atomic absorption spectrometric determination.

S A M Fathi et al.

Journal of hazardous materials, 164(1), 133-137 (2008-09-10)

Bis(5-bromo-2-hydroxybenzaldehyde)-1,2-propanediimine is synthesized by the reaction of 5-bromo-2-hydroxybenzaldehyde and 1,2-diaminopropane in ethanol. This ligand is used as a modifier of octadecyl silica disks for preconcentration of trace amounts of copper(II) ions, followed by nitric acid elution and flame atomic absorption

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