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202495

Sigma-Aldrich

Poly(ethylene glycol) methyl ether

average MN 750, methoxy, hydroxyl

Synonym(s):

Polyethylene glycol, Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, mPEG

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About This Item

Linear Formula:
CH3(OCH2CH2)nOH
CAS Number:
9004-74-4
MDL number:
MFCD00084416
UNSPSC Code:
12162002
PubChem Substance ID:
24852093
NACRES:
NA.23

product name

Poly(ethylene glycol) methyl ether, average Mn 750

vapor density

>1 (vs air)

vapor pressure

0.05 mmHg ( 20 °C)

form

paste
solid

mol wt

average Mn 750

refractive index

n20/D 1.459

viscosity

10.5 cSt(210 °F)(lit.)

transition temp

Tm 30 °C

density

1.094 g/mL at 25 °C

Ω-end

hydroxyl

α-end

methoxy

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3

InChI key

XNWFRZJHXBZDAG-UHFFFAOYSA-N

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Application

Poly(ethylene glycol) methyl ether can be used:
  • As a chain transfer agent to synthesize amphiphilic block copolymers by metal-free ring-opening oligomerization.
  • As a precursor to prepare retinoic acid-polyethylene glycol nanoassembly as an efficient drug delivery system.
  • To prepare diblock copolymer with polylactic acid, which can be applied in the field of tissue engineering and drug delivery.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

359.6 °F - closed cup

Flash Point(C)

182 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yi Wei et al.
Langmuir : the ACS journal of surfaces and colloids, 28(39), 13984-13992 (2012-09-04)
The microcosmic mechanisms of protein (recombinant human growth hormone, rhGH) incomplete release and stability from amphiphilic poly(monomethoxypolyethylene glycol-co-D,L-lactide) (mPEG-PLA, PELA) microspheres were investigated. PELA with different hydrophilicities (PELA-1, PELA-2, and PELA-3) based on various ratios of mPEG to PLA were
Prakash G Avaji et al.
Bioorganic & medicinal chemistry letters, 23(6), 1763-1767 (2013-02-16)
Saturated fatty acids (FA) were grafted using tyrosine as a spacer group to the cyclotriphosphazene ring along with equimolar hydrophilic methoxy poly(ethylene glycol) (MPEG) in cis-nongeminal way. Seven new cyclotriphosphazene amphiphiles were prepared from combinations of hydrophilic MPEGs with different
Mulu Z Tesfay et al.
Journal of virology, 87(7), 3752-3759 (2013-01-18)
We are developing oncolytic vesicular stomatitis viruses (VSVs) for systemic treatment of multiple myeloma, an incurable malignancy of antibody-secreting plasma cells that are specifically localized in the bone marrow. One of the presumed advantages for using VSV as an oncolytic
Seung-Young Lee et al.
Biomaterials, 34(2), 552-561 (2012-10-20)
Although targeted delivery mediated by ligand modified or tumor microenvironment sensitive nanocarriers has been extensively pursued for cancer chemotherapy, the efficiency is still limited by premature drug release after systemic administration. Herein we report a highly blood-stable, tumor-adaptable drug carrier
Lina Du et al.
Anti-cancer drugs, 24(2), 172-180 (2012-09-20)
A functionalized poly(amidoamine) (PAMAM) nanocarrier was designed and prepared to deliver anticancer drugs. The nanocarrier is a copolymer with a core-shell structure with 3.0 G PAMAM as the core and sequentially conjugated poly(2-(N,N-diethylamino)ethyl methacrylate) (pDEA) and methoxy-poly(ethylene glycol) 2000 (mPEG)
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