SRP8001

Calreticulin human

recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)

• 別名: CRP55, Calregulin, ERp60, Endoplasmic reticulum resident protein 60, grp60
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 由来生物: human
• リコンビナント: expressed in E. coli
• タグ: His tagged
• アッセイ: >90% (SDS-PAGE)
• フォーム: liquid
• 分子量: ~55 kDa by SDS-PAGE
• 包装: pkg of 10 μg
• 保管条件: avoid repeated freeze/thaw cycles
• テクニック: calcium flux assay: suitable
• 不純物: <1 EU/μg endotoxin, tested
• UniProtアクセッション番号: P27797
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... CALR(811)

詳細

詳細

Calreticulin (CALR) is expressed in the endoplasmic reticulum. The gene encoding it is localized on human chromosome 19p13.13.

アプリケーション

Human calreticulin has been used in a study to determine the effects of uncoupling protein 4 (UCP4) on the expression of proteins in the store-operated Ca²⁺ entry pathway.

生物化学的／生理学的作用

Calreticulin is involved in regulation of intracellular Ca²⁺ homoeostasis and ER Ca²⁺ capacity. It constitutes together with calnexin and ERp57 the ′calreticulin/calnexin cycle′ that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.

物理的形状

Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl.

その他情報

Human calreticulin (aa18-417) is fused at the C-terminus to a His-tag.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable