SML0907

Apoptolidin A Ready Made Solution

1 mg/mL in DMSO

• 別名: Apoptolidin, FU 40A
• 実験式（ヒル表記法）: C₅₈H₉₆O₂₁
• CAS番号: 194874-06-1
• 分子量: 1129.37
• EC Number: 200-664-3
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825615
• NACRES: NA.77

特性

• 由来生物: Amycolatopsis sp.
• 品質水準: 200
• 形状: DMSO solution
• 濃度: 1 mg/mL in DMSO
• 抗生物質活性スペクトル: fungi
• 作用機序: enzyme | inhibits
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: CC(/C=C1\C)=C\C(C)=C\[C@@H](C)[C@H](O[C@H]2[C@@H](O)[C@H](O)[C@@H](OC)[C@H](C)O2)/C=C/C(C)=C/CC[C@H](O)[C@@H](OC)CC([C@H]([C@]3([C@H](C)[C@@H](O)[C@@H](C)C(C[C@H](COC)O[C@H]4C[C@@](O)(C)[C@@H](O[C@H]5C[C@@H](OC)[C@H](O)[C@H](C)O5)[C@H](C)O4)O3)O)O)OC1=O
• InChI: 1S/C58H96O21/c1-29-17-16-18-40(59)43(69-13)25-45(76-55(65)33(5)23-31(3)21-30(2)22-32(4)41(20-19-29)77-56-51(63)50(62)52(71-15)37(9)74-56)53(64)58(67)35(7)48(60)34(6)42(79-58)24-39(28-68-12)75-47-27-57(11,66)54(38(10)73-47)78-46-26-44(70-14)49(61)36(8)72-46/h17,19-23,32,34-54,56,59-64,66-67H,16,18,24-28H2,1-15H3/b20-19+,29-17+,30-22+,31-21+,33-23+/t32-,34+,35-,36+,37+,38+,39-,40+,41-,42?,43+,44-,45?,46+,47+,48+,49-,50+,51+,52+,53-,54+,56+,57+,58-/m1/s1
• InChI Key: WILMROCKORZEMQ-XIQAQMKHSA-N

詳細

詳細

Chemical structure: macrolide

生物化学的／生理学的作用

Apoptolidin A is a 20-membered macrolide shown to be selectively cytotoxic against several cancer cell lines and noncytotoxic against normal cells. The molecule was originally produced by Nocardiopsis species, and its target site was identified as mitochondrial F₀F₁-ATPase.
Apoptolidin induces apoptosis selectively in rat glia cells transformed with the adenovirus oncogene E₁A. Several minor apoptolidin congeners were isolated, known as Apoptolidins A-D. All apoptolidins were reported to inhibit growth of H292 cancer cells (lung carcinoma) in the submicromolar range. Recently, a stereo-selective synthesis of the Apoptolidin disaccharide was reported.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): 188.6 °F
• 引火点(℃): 87 °C