SAB1306492

ANTI-ZO1(C-TERMINAL) antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

• 別名: TJP1, Tight junction protein 1, Tight junction protein ZO-1, ZO1, Zona occludens protein 1
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: 195459 Da
• 化学種の反応性: human
• テクニック: flow cytometry: 1:10-1:50; immunohistochemistry: 1:50-1:100; western blot: 1:1000
• NCBIアクセッション番号: NP_003248.3
• UniProtアクセッション番号: Q07157
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TJP1(7082)

詳細

詳細

Tight junction protein 1 (TJP1) or zona occludens protein 1 (ZO1) is an adaptor protein. It acts as a scaffold protein between the tight junction and actin cytoskeleton. ZO1 has a molecular weight of 220kDa and is part of the membrane-associated guanylate kinase homolog family. The protein possesses three PDZ domains at its amino terminal, an SH3 domain and a region which bears homology to guanylate kinase. The ZO1 gene is localized on human chromosome 15q13.1.

アプリケーション

ANTI-ZO1(C-TERMINAL) antibody produced in rabbit has been used in immunofluorescence.

生物化学的／生理学的作用

Tight junction protein 1 (TJP1) or zona occludens protein 1 (ZO1) has a role in the formation of epithelial lumens. It interacts with occludin and modulates tight junction barrier regulation. ZO1 is also involved in the formation of the odontoblast layer and in actomyosin cytoskeleton regulation. Low expression of ZO1 has been linked to increased cell invasiveness in breast cancer, colorectal cancer and digestive tract cancers.

物理的形状

PBS（0.09％ （W/V）アジ化ナトリウム含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable