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1643907

USP

Terfenadine Related Compound A

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Terfenadone, 1-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-butanone

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About This Item

Empirical Formula (Hill Notation):
C32H39NO2
CAS Number:
76815-60-6
Molecular Weight:
469.66
Beilstein:
6352257
MDL number:
MFCD09837939
UNSPSC Code:
41116107
PubChem Substance ID:
329751239
NACRES:
NA.24

grade

pharmaceutical primary standard

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(C)(C)c1ccc(cc1)C(=O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4

InChI

1S/C32H39NO2/c1-31(2,3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29,35H,10,15,20-24H2,1-3H3

InChI key

YCADFOXVGUGHRV-UHFFFAOYSA-N

General description

Terfenadine Related Compound A also called as terfenadine is derivative of terfenadine. It is mostly used as starting point for the designing of high-affinity inhibitors of CYP2J2.

Application

It was used as internal standard during determination of terfenadine in human plasma using HPLC-MS/MS analysis.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.
Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

1643907-100MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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High sensitivity high performance liquid chromatography electrospray tandem mass spectrometry determination of terfenadine in human plasma.
Lau, Yau Yi, Paul H. Anderson, and Rasmy Talaat.
Journal of Liquid Chromatography and Related Technologies, 19.16, 2669-2679 (1996)
Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo.
Chen C
Journal of Pharmacology and Experimental Therapeutics, 329(3), 908-918 (2009)

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