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G005907

HPLC Analysis of Aflatoxins in Wheat on Ascentis® Express C18 after SPE using Supel Tox AflaZea

application for HPLC

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technique(s)

HPLC: suitable

test parameters

sample preparation: SPE (Solid Phase Extraction)
sample/matrix: 25 g wheat meal spiked with pesticide standards
SPE tube/cartridge: SupelTox AflaZea, 6 mL (55314-U)
sample addition: 2 mL
elution: collect eluate in 5 mL silanized culture tubes
eluate post-treatment: combine 200 μL of sample eluate and 880 μL of DI water in a 2 mL autosampler vial
column: Ascentis Express C18, 10 cm x 2.1 mm I.D., 2.7 μm particles (53823-U)
mobile phase: [A] water; [B] methanol; [C] acetonitrile; (720:120:120, A:B:C) containing 0.780 g/L potassium bromide, 230 μL/L nitric acid
flow rate: 0.400 mL/min
pressure: 4568 psi (315 bar)
column temp.: 35 °C
detector: FLD 360 ex; 440 em
injection: 20 μL
derivatization: via KOBRA electrochemical cell, 50 μA

suitability

application for HPLC

application(s)

food and beverages

Analysis Note

Sample/matrix:
Weigh 25 grams of wheat meal into a 500 mL Erlenmeyer flask. Add 100 mL of 84:16 acetonitrile:water, seal, and place on an orbital shaker at med-high speed for 90 minutes. Filter the sample through a #2 qualitative filter. Spike sample at 2 mg/mL using analytical standards.

Legal Information

Ascentis is a registered trademark of Merck KGaA, Darmstadt, Germany
Supel is a trademark of Sigma-Aldrich Co. LLC

Analyte

Description

    Aflatoxin G2
    Aflatoxin G1
    Aflatoxin B2
    Aflatoxin B1

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