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Key Documents

Safety Information

V8250

Sigma-Aldrich

Snake venom from Echis carinatus

Synonym(s):

Saw-scaled Viper

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.25

Quality Level

200

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

Application

Snake venom from Echis carinatus (Indian saw-scaled viper) which acts primarily on fibrinogen may be used as a source of anticoagulation factors and the prothrombin activator ecarin. It may also be used as an immunogen.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300 + H310

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

V8250-1G:
V8250-10MG-PW:
V8250-BULK:
V8250-100MG:
V8250-25MG:
V8250-VAR:
V8250-100MG-PW:
V8250-10MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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John Kim et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(8), 663-671 (2015-02-13)
1. The safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect of LB30870, a new selective thrombin inhibitor, were studied in 16 healthy men. 2. A double-blind, placebo-controlled single ascending dose study was done at oral doses of 5, 15, 30, 60, 120, and
Riley B Peacock et al.
Biochemistry, 57(18), 2694-2703 (2018-04-11)
Thrombin normally cleaves fibrinogen to promote coagulation; however, binding of thrombomodulin to thrombin switches the specificity of thrombin toward protein C, triggering the anticoagulation pathway. The W215A thrombin mutant was reported to have decreased activity toward fibrinogen without significant loss
Effects of snake venom proteases on human fibrinogen chains.
Cortelazzo A, Guerranti R, Bini L, et al.
Blood, 8, 120-125 (2010)
K Paul et al.
Toxicon : official journal of the International Society on Toxinology, 50(7), 893-900 (2007-08-08)
High titer antibodies (IgY) were raised in egg yolk of white leghorn chicken (Gallus gallus domesticus) by immunizing with the venom of Echis carinatus (Saw scaled viper or carpet viper), an Indian venomous snake belonging to the family Viperidae. The
Isolation and partial purification of anticoagulant fractions , from the venom of the Iranian snake Echis carinatus.
Babaie M, Zolfagharian H, et al.
Bioengineered (2012)

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