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U116

Sigma-Aldrich

U-99194 maleate salt

≥98% (HPLC), solid

Synonym(s):

5,6-Dimethoxy-2-(di-n-propylamino)indan maleate salt

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About This Item

Empirical Formula (Hill Notation):
C17H27NO2 · C4H4O4
CAS Number:
234757-41-6
Molecular Weight:
393.47
MDL number:
MFCD01529985
UNSPSC Code:
12352200
PubChem Substance ID:
24277946
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

color

white

solubility

H2O: >5 mg/mL

SMILES string

OC(=O)\C=C/C(O)=O.CCCN(CCC)C1Cc2cc(OC)c(OC)cc2C1

InChI

1S/C17H27NO2.C4H4O4/c1-5-7-18(8-6-2)15-9-13-11-16(19-3)17(20-4)12-14(13)10-15;5-3(6)1-2-4(7)8/h11-12,15H,5-10H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

FSIQDESGRQTFNN-BTJKTKAUSA-N

Gene Information

human ... DRD3(1814)

Application

U-99194 maleate has been used as a dopaminergic antagonist to study its effects on immobility episodes and yawning frequency in rats.

Biochem/physiol Actions

U-99194 is a putative D3 antagonist with a 30-fold preference for the dopamine D3 vs. D2 receptor.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

U-99194 maleate salt is soluble in water at a concentration >5 mg/ml.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

U116-IP:
U116-100MG:
U116-25MG:
U116-BULK:
U116-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
063M4610V
086K46132
086K46131
086K4613
050K4606

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Jose R Eguibar et al.
Neuroscience letters, 483(3), 189-192 (2010-08-10)
The taiep rat is a myelin mutant whose immobility episodes (IEs) can be caused by gripping them by the tail. Electroencephalographic recordings during IEs show a rapid-eye movement sleep-like pattern, similar to narcolepsy-cataplexy in canines. Systemic administration of alpha(2)-adrenoceptor agonists
T Kling-Petersen et al.
Journal of neural transmission. General section, 102(3), 209-220 (1995-01-01)
Compounds showing an in vitro binding preference for the dopamine D3 vs. D2 receptors were tested for effects on locomotor activity after local application in the nucleus accumbens (N Acc) and the ventral tegmental area (VTA) of the rat brain.
Jose R Eguibar et al.
Pharmacology, biochemistry, and behavior, 102(1), 118-123 (2012-04-14)
Systemic administration of D2-like dopaminergic-receptor agonists increases yawning behavior. However, only a few studies have been done in animals with pathological conditions. The taiep rat is a myelin mutant with an initial hypomyelination followed by progressive demyelination, being the brainstem
N Waters et al.
Journal of neural transmission. General section, 94(1), 11-19 (1993-01-01)
We report on the pharmacological effects of the 20 fold D3 vs. D2 dopamine receptor preferring compound U99194A. It is shown that U99194A increases rat locomotor activity at doses that do not increase release or utilisation of dopamine in the

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