TRUERGD

TrueGel3D RGD

Integrin Adhesion Peptide

• Synonym(s): 3D cell culture matrix
• UNSPSC Code: 12352207
• NACRES: NA.71

Properties

• shipped in: dry ice
• storage temp.: −20°C

Description

General description

RGD sequences on extracellular matrix proteins (fibronectin, vitronectin) promote cell adhesion to cellular integrin receptors. The thiol group on the N-terminus of TrueGel3D^® RGD peptide acts as linker to bind RGD motif to the polymer (Dextran/PVA). The conjugated RGD motif on polymer promotes adhesion of cells with appropriate integrin receptors.

TrueGel3D^® is a commercially available polymer-based diverse array of scaffolds for 3D in vitro tumor models. The RGD peptide present in these hydrogels enable cell attachment.

Application

Polymer with cell adhesion motif (RGD) employed to generate cell-adhesive hydrogel

Features and Benefits

Contains cell adhesion motif RGD (Acetyl-Cys-Doa*-Doa-Gly-Arg-Gly-Asp-Ser-Pro-NH2), which binds to appropriate integrin receptors on cells.

*Doa : 8-amino-3,6-dioxaoctanoic acid

Components

TRUERGD contains RGD degradable polymer lyophilized and water

Legal Information

TRUEGEL3D is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids