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Safety Information

T1145

Sigma-Aldrich

L-Tyrosine disodium salt hydrate

BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98% (HPLC)

Synonym(s):

L-3-(4-Hydroxyphenyl)alanine disodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):
C9H9NNa2O3 · xH2O
CAS Number:
69847-45-6
Molecular Weight:
225.15 (anhydrous basis)
MDL number:
MFCD08276422
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24899937
NACRES:
NA.75

product line

BioReagent

Quality Level

300

Assay

≥98% (HPLC)

form

powder

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable

color

white to beige

storage temp.

2-8°C

SMILES string

O.[Na+].[Na+].N[C@@H](Cc1ccc([O-])cc1)C([O-])=O

InChI

1S/C9H11NO3.2Na.H2O/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;;;/h1-4,8,11H,5,10H2,(H,12,13);;;1H2/q;2*+1;/p-2/t8-;;;/m0.../s1

InChI key

SMJHYQCAVHUILN-CZDIJEQGSA-L

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General description

Tyrosine is a polar, non-essential amino acid with a phenolic functionality. L-tyrosine is a natural amino acid that is incorporated into proteins as directed by the genetic code. The phenolic function makes the tyrosine residue in proteins a principle recipient of reactions such as phosphorylation/dephosphorylation important for cell signalling. Tyrosine is also a precursor of various neurotransmitters and hormones.

Other Notes

Amino acid precursor of dopamine and other catecholamines

Caution

Extremely hygroscopic.

Suitability

This product has been qualified for use in insect cell cultures.

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H318

Precautionary Statements

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

T1145-VAR:
T1145-100G:
T1145-500G:
T1145-25G:
T1145-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ching-Hsia Hung et al.
European journal of pharmacology, 765, 457-462 (2015-09-17)
The purpose of the study was to estimate the ability of L-tyrosine to induce cutaneous analgesia and to investigate the interaction between L-tyrosine and the local anesthetic lidocaine. After subcutaneously injecting the rats with L-tyrosine and lidocaine in a dose-dependent
Zihao Wang et al.
Science signaling, 3(104), ra2-ra2 (2010-01-14)
Like phosphorylation, the addition of O-linked beta-N-acetylglucosamine (O-GlcNAcylation) is a ubiquitous, reversible process that modifies serine and threonine residues on nuclear and cytoplasmic proteins. Overexpression of the enzyme that adds O-GlcNAc to target proteins, O-GlcNAc transferase (OGT), perturbs cytokinesis and
Airi Sekine et al.
SpringerPlus, 4, 48-48 (2015-02-13)
The tryptophan metabolite, kynurenic acid (KYNA), is a preferential antagonist of the α7 nicotinic acetylcholine receptor at endogenous brain concentrations. Recent studies have suggested that increase of brain KYNA levels is involved in psychiatric disorders such as schizophrenia and depression.

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