Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

SRP8059

Sigma-Aldrich

Jagged-2 (human): FC (human)

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

Synonym(s):

Alpha-ketoglutarate-dependent dioxygenase FTO, Protein jagged-2, hJ2

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

recombinant

expressed in HEK 293 cells

Assay

≥90% (SDS-PAGE)

form

lyophilized

mol wt

~150 kDa by SDS-PAGE

impurities

<0.1 EU/μgtested

UniProt accession no.

Q9Y219

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... JAG2(3714)

General description

Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.

Sequence

Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG.

Physical form

Lyophilized. Contains PBS + 0.02 % CHAPS.

Reconstitution

Reconstitute with 100μl sterile water.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP8059-10UG:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service