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Key Documents

Safety Information

SRP8036

Sigma-Aldrich

IL-36β mouse

>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized

Synonym(s):

Interleukin-1 family member 8, Interleukin-36β, Sentrin-specific protease 2

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

product name

IL-36β mouse, recombinant, expressed in E. coli, untagged, >95% (SDS-PAGE)

biological source

mouse

recombinant

expressed in E. coli

conjugate

untagged

Assay

>95% (SDS-PAGE)

form

lyophilized

mol wt

~17 kDa

packaging

pkg of 10 μg

impurities

<0.01 EU/μg endotoxin, tested

color

white

UniProt accession no.

Q9D6Z6

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Il36b(69677)

General description

IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.

Physical form

Lyophilized from PBS and 0.5% trehalose.

Reconstitution

Reconstitute with 100 μL deionized water.

Other Notes

IL-36beta (mouse) (aa 31-183) is untagged.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP8036-10UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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