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Safety Information

SRP6301

Sigma-Aldrich

Apolipoprotein A-IV from human plasma

≥85% (SDS-PAGE)

Synonym(s):

Apo-AIV, ApoA-IV, Apolipoprotein A-IV, apo AIV

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human plasma

Assay

≥85% (SDS-PAGE)

form

frozen liquid

mol wt

46 kDa

packaging

pkg of 50 μg

UniProt accession no.

P06727

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... ApoA4(337)

General description

Apolipoprotein (apo)A-IV4 is a lipid-binding protein. It is produced by the small intestine and liberated into the gastric lymphatics. A-IV4 belongs to the exchangeable apolipoproteins family. This gene is located on human chromosome 11q23.
Apolipoprotein AIV (Apo AIV) is a glycoprotein synthesized by the human intestine. Synthesis appears to be stimulated by the absorption of high density lipoproteins that are rich in triglycerides rather than by the uptake or re-esterification of fatty acids. The formation of chylomicrons acts as a signal for the induction of Apo AIV synthesis a signal enhanced by a factor from the ileum, probably PYY. Apo AIV alters the activity of the key enzymes (LPL and LCAT) of lipoprotein metabolism and cholesterol efflux from extra hepatic tissues. Also, since stimulation of intestinal synthesis and secretion by lipid absorption are rapid, Apo AIV likely plays a role in the short-term regulation of food intake. Other evidence suggests involvement in the long-term regulation of both food intake and body weight. Chronic ingestion of high-fat diet blunts the intestinal Apo AIV response to lipid feeding and, consequently, may explain why the chronic ingestion of a high-fat diet predisposes both animals and humans to obesity. It is required for efficient activation of lipoprotein lipase by ApoC-II and is a potent activator of LCAT. Apo AIV is an amphipathic protein that can emulsify lipids and has been linked to protective roles against cardiovascular disease and obesity.

Biochem/physiol Actions

Apolipoprotein (apo)A-IV participates in dietary lipid and glucose metabolism. It inhibits oxidation of lipids and represses inflammation. A-IV plays a major role in changing the glucose sensitivity of pancreatic islets to alter insulin secretion.

Physical form

Frozen in 10 mM NH4HCO3, pH 8.2.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP6301-50UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Role of conserved proline residues in human apolipoprotein A-IV structure and function.
Deng X, et al.
The Journal of Biological Chemistry, 290(17), 10689?10702-10689?10702 (2015)
Effects of interacting networks of cardiovascular risk genes on the risk of type 2 diabetes mellitus (the CODAM study).
van Greevenbroek MM, et al.
BMC Medical Genetics, 9(1), 36-36 (2008)
The Structure of Human Apolipoprotein A-IV as Revealed by Stable Isotope Assisted Cross-linking, Molecular Dynamics and Small Angle X-ray Scattering.
Walker RG, et al.
The Journal of Biological Chemistry, 289(9), 5596?5608-5596?5608 (2014)

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