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Safety Information

SRP6003

Sigma-Aldrich

Procalcitonin human

recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)

Synonym(s):

CALC1, CALCA, CGRP, Calcitonin

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About This Item

CAS Number:
1476823-80-9
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥97% (HPLC)
≥97% (SDS-PAGE)

form

lyophilized

potency

80 ng/mL

mol wt

12.796 kDa

packaging

pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

impurities

Endotoxin, tested

NCBI accession no.

P01258

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... N/A(796)

General description

The gene CALC1 (calcitonin 1) is mapped to human chromosome 11. CALC1 encodes for preprocalcitonin. Preprocalcitonin is cleaved by endopeptidase at the amino-terminal to produce procalcitonin. Procalcitonin works as a peptide hormone and is mainly produced by the C cells of the thyroid and certain endocrine cells of the lung. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments, an N terminal residue, calcitonin and katacalcin. Recombinant human procalcitonin produced in Escherichia coli is a single, non-glycosylated, polypeptide chain containing 116 amino acids with a molecular weight of 12,796 Daltons.

Application

Procalcitonin human has been used in in vitro vascular permeability assay.

Biochem/physiol Actions

Procalcitonin is a prohormone of calcitonin. Levels of unprocessed procalcitonin rise significantly after bacterial infection, trauma or shock. Procalcitonin is also associated with systemic complications in humans suffering from acute pancreatitis.

Physical form

Lyophilized from a 10 mM sodium phosphate buffer, pH 7.5.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile H?O to a concentration of 0.1 mg/ml.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP6003-10UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nana-Maria Wagner et al.
Anesthesia and analgesia, 124(3), 836-845 (2016-09-23)
Procalcitonin is used as a diagnostic tool for the identification and risk stratification of septic patients. Procalcitonin plasma concentrations tightly correlate with the severity of the ongoing inflammatory reaction and can rise up to 10,000-fold. Impairment of endothelial cell function
Physiology and genetics of procalcitonin.
Maruna P
Physiological Research, 49, S57-S61 (2000)
The potential role of procalcitonin and interleukin 8 in the prediction of infected necrosis in acute pancreatitis.
Rau B
Gut, 41, 832-832 (1997)
Procalcitonin as an acute phase marker.
Annals of Clinical Biochemistry, 38, 483-493 (2001)
High serum procalcitonin concentrations in patients with sepsis and infection.
Lancet, 341, 515-518 (1993)
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