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SRP3144

Sigma-Aldrich

PLGF-3 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture

Synonym(s):

PGFL, Placenta Growth Factor-3

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

potency

5.0-50.0 ng/mL

mol wt

45.7 kDa

packaging

pkg of 25 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white

UniProt accession no.

P49763

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... PGF(5228)

General description

PLGF (placental growth factor), originally identified in human placenta, is a member of the VEGF (vascular endothelial growth factor) family. This protein is predominantly expressed in placenta, and also shows expression in heart, thyroid, lung and skeletal muscle. It is alternatively spliced to produce four isoforms in humans namely, PLGF1, PLGF2, PLGF3 and PLGF4. PLGF gene is localized to human chromosome 14q24, spans 800kb and is composed of seven exons.
Recombinant human PlGF-3 is a 45.7kDa disulfide-linked homodimeric protein of two 203 amino acid polypeptide chains.

Biochem/physiol Actions

PLGF (placental growth factor) is involved in angiogenesis, but does not play an essential role in angiogenesis during reproduction and development. However, inactivation of this gene in pathological conditions such as, ischemia, inflammation and cancer, results in impaired angiogenesis. Preclinical studies show that this protein might be a therapeutic target for treatment of angiogenesis and inflammation related disorders. In acute coronary syndrome (ACS) patients, increased levels of PLGF are linked with obstructive sleep apnea (OSA) and short-term adverse outcomes.

Sequence

LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSEYPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK IRSGDRPSYV ELTFSQHVRC ECRHSPGRQS PDMPGDFRAD APSFLPPRRS LPMLFRMEWG CALTGSQSAV WPSSPVPEEI PRMHPGRNGK KQQRKPLREK MKPERCGDAV PRR

Physical form

Lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP3144-25UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Impact of Obstructive Sleep Apnea on the Levels of Placental Growth Factor (PlGF) and Their Value for Predicting Short-Term Adverse Outcomes in Patients with Acute Coronary Syndrome.
Barcelo A et al
PLoS ONE, 11(3), e0147686-e0147686 (2016)
PlGF: a multitasking cytokine with disease-restricted activity.
Dewerchin M et al
Cold Spring Harbor Perspectives in Biology, 2(8)-2(8) (2012)
Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders.
Autiero M, et al.
Journal of Thrombosis and Haemostasis, 1(7), 1356-1370 (2003)
Wen Yang et al.
Journal of reproductive immunology, 60(1), 53-60 (2003-10-22)
Placenta growth factor (PlGF), a homodimeric glycoprotein that is homologous to vascular endothelial growth factor (VEGF), is mitogenic to endothelial cells and protects trophoblast from apoptosis. Alternative splicing of mature mRNA gives rise to three known isoforms of PlGF. PlGF

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