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Key Documents

SRP0466

Sigma-Aldrich

BRDT (22-138) His tag human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(s):

BRD6, CT9, bromodomain, testis-specific

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

form

aqueous solution

mol wt

14.9 kDa

packaging

pkg of 100 μg

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... BRDT(676)

General description

Human Bromodomain testis-specific protein, also known as BRDT, BRD6, and CT9 (GenBank Accession No. NM_207189) amino-acids 22 – 138 with N-terminal HIS-tag, MW = 14.9 kDa, expressed in an E. coli expression system.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Enyuan Shang et al.
Development (Cambridge, England), 134(19), 3507-3515 (2007-08-31)
Brdt is a testis-specific member of the distinctive BET sub-family of bromodomain motif-containing proteins, a motif that binds acetylated lysines and is implicated in chromatin remodeling. Its expression is restricted to the germ line, specifically to pachytene and diplotene spermatocytes
Binyamin D Berkovits et al.
Developmental biology, 360(2), 358-368 (2011-10-25)
Mice homozygous for a mutation (Brdt(∆BD1/∆BD1)) lacking the first bromodomain of Brdt, a testis-specific member of the BET family of double-bromodomain containing proteins, are sterile and exhibit profound defects in chromatin remodeling during spermiogenesis. We have now observed that a

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