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Key Documents

Safety Information

SRP0462

Sigma-Aldrich

BRD4 (342-460) His tag human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(s):

CAP, HUNK1, HUNKI, MCAP, bromodomain containing 4

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

form

aqueous solution

mol wt

14.7 kDa

packaging

pkg of 100 μg

NCBI accession no.

NM_058243

UniProt accession no.

O60885

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... BRD4(23476)

General description

Human Bromodomain containing 4, also known as BRD4, HUNK1, or MCAP (GenBank Accession No. NM_058243) amino-acids 342-460 with N-terminal His-tag, MW = 14.7 kDa, expressed in an E. coli expression system.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP0462-100UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Philipp Voigt et al.
Genome biology, 12(11), 133-133 (2011-12-01)
The chromatin adapter BRD4 may be crucial for transmitting epigenetic information by acting as a histone acetylation-dependent gene bookmark and accelerating post-mitotic transcriptional reactivation.
R M Rodriguez et al.
Journal of molecular medicine (Berlin, Germany), 90(5), 587-595 (2011-11-29)
The bromodomain protein BRD4 is involved in cell proliferation and cell cycle progression, primarily through its role in acetylated chromatin-dependent regulation of transcription at targeted loci. Here, we show that BRD4 is frequently downregulated by aberrant promoter hypermethylation in human

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