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Key Documents

Safety Information

SRP0422

Sigma-Aldrich

PARP5A active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥30% (SDS-PAGE)

Synonym(s):

PARP5a, TNKS1, Tankyrase1, poly(ADP-ribosyl)transferase 5a

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

Assay

≥30% (SDS-PAGE)

form

aqueous solution

mol wt

62.5 kDa

packaging

pkg of 10 μg

NCBI accession no.

NM_003747

UniProt accession no.

O95271

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... TNKS(8658)

General description

TNKS1 (TRF1-interacting ankyrin-related ADP-ribose polymerase 1), also known as PARP5A, TANK1, or tanykyrase-1 (GenBank Accession No. NM_003747), amino acids 1000-1328 (end) with N-terminal GST-tag, MW=62.5 kDa, expressed in Sf9 cells via a Baculovirus expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Cartagena Act

Cartagena Act Listed

JAN Code

SRP0422-10UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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N McCabe et al.
Oncogene, 28(11), 1465-1470 (2009-02-03)
The BRCA1 and BRCA2 proteins are involved in the maintenance of genome stability and germ-line loss-of-function mutations in either BRCA1 or BRCA2 strongly predispose carriers to cancers of the breast and other organs. It has been demonstrated previously that inhibiting
Courtney M Karner et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 239(7), 2014-2023 (2010-06-16)
Recent studies using small molecule antagonists have revealed that the poly(ADP-ribose) polymerases (PARPs) Tankyrase 1 and 2 are critical regulators of canonical Wnt signaling in some cellular contexts. However, the absence of any activity during zebrafish embryogenesis suggested that the
Sandy Chang
Aging, 2(10), 639-642 (2010-11-16)
The proliferative potential of eukaryotic cells is critically dependent upon the maintenance of functional telomeres, the protein-DNA complexes that cap the ends of chromosomes. A paper published in this issue of Aging describes that the telomere protein tankyrase 1 regulates

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