SML3922
A-784168
≥98% (HPLC)
Synonym(s):
1-[3-(Trifluoromethyl)pyridin-2-yl]-N-[4-(trifluoromethylsulfonyl)phenyl]-1,2,3,6-tetrahydropyridine-4-carboxamide, 3′-(Trifluoromethyl)-N-{4-[(trifluoromethyl)thio]phenyl}-3,6-dihydro-2H-1,2′-bipyridine-4-carboxamide, A 784168, A784168
About This Item
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
A-784168 is a brain-penetrant, orally active, potent and selective transient receptor potential (TRP) cation channel TRPV1 antagonist (IC50 = 25/14/33.7/35.1 nM against TRPV1 activation by 50 nM capsaicin/pH 5.5/3 µM NADA/10 µM anandamide in human TRPV1 tranfectants) with little activity or affinity toward other TRP channels and a panel of 74 neurotransmitter receptors. A-784168 reduces capsaicin-induced acute pain (ED50 = 10 µmol/kg p.o. 1h before capsaicin intraplantar injection) and CFA paw injection-induced chronic inflammatory thermal hyperalgesia (EC50 = 54 nmol) in rats in vivo.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
JAN Code
SML3922-5MG:
SML3922-BULK:
SML3922-25MG:
SML3922-VAR:
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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