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Safety Information

SML3677

Sigma-Aldrich

Cryosim-3

≥98% (HPLC)

Synonym(s):

1-Di(isopropyl)phosphinoyl-nonane, 1-Diisopropylphosphorylnonane, Bis(1-methylethyl)nonylphosphine oxide, DIPA 1-9

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About This Item

Empirical Formula (Hill Notation):
C15H33OP
CAS Number:
1507344-37-7
Molecular Weight:
260.40
UNSPSC Code:
12352200
NACRES:
NA.25

Quality Level

100

Assay

≥98% (HPLC)

form

oil

color

colorless to yellow

storage temp.

2-8°C

SMILES string

O=P(C(C)C)(C(C)C)CCCCCCCCC

InChI key

DHOTYMJGZIUWRT-UHFFFAOYSA-N

Biochem/physiol Actions

Cryosim-3 is a water soluble, selective and potent agonist of TRPM8 (transient receptor potential melastatin 8) receptor. Cryosim-3 increases tear secretion in an animal model of dry eye disease. Also it relieves ocular discomfort in subjects diagnosed with DED without eye irritation.
Water soluble, selective and potent agonist of TRPM8 receptor

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML3677-BULK:
SML3677-25MG:
SML3677-5MG:
SML3677-VAR:

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Ying Yin et al.
Science (New York, N.Y.), 378(6616), eadd1268-eadd1268 (2022-10-14)
The transient receptor potential melastatin 8 (TRPM8) channel is the primary molecular transducer responsible for the cool sensation elicited by menthol and cold in mammals. TRPM8 activation is controlled by cooling compounds together with the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2).

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