Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

SML3467

Sigma-Aldrich

Remimazolam

≥98% (HPLC)

Synonym(s):

(S)-Methyl 3-(8-bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,2-a][1,4]diazepin-4-yl)propanoate, CNS 7054 methyl ester, CNS 7056, CNS-7054 methyl ester, CNS-7056, CNS7054 methyl ester, CNS7056, Methyl 3-{(4S)-8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl}propanoate, ONO 2745, ONO-2745, ONO2745

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C21H19BrN4O2
CAS Number:
308242-62-8
Molecular Weight:
439.31
MDL number:
MFCD18633229
UNSPSC Code:
12352200

Quality Level

100

Assay

≥98% (HPLC)

form

powder

drug control

USDEA Schedule IV

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

CC1=CN=C2[C@H](CCC(OC)=O)N=C(C3=CC=CC=N3)C4=CC(Br)=CC=C4N12

InChI

1S/C21H19BrN4O2/c1-13-12-24-21-17(7-9-19(27)28-2)25-20(16-5-3-4-10-23-16)15-11-14(22)6-8-18(15)26(13)21/h3-6,8,10-12,17H,7,9H2,1-2H3/t17-/m0/s1

InChI key

CYHWMBVXXDIZNZ-KRWDZBQOSA-N

Biochem/physiol Actions

Remimazolam (CNS 7056) is a benzodiazepine derivative with positive allosteric modulator (PAM) activity toward γ-aminobutyric acid type A (GABAA) receptor (pKi = 7.53/7.50/7.56 against 2.5 nM flunitrazepam for binding human/rat/yucatan micropig brain homogenates; pEC50/Emax = 6.44/375% (α1β2γ2), 6.18/186% (α2β2γ2), 6.04/210% (α3β2γ2), 5.86/289% (α5β2γ2s) by whole cell patch clamp using cells expressing respective rat αβγ complex). Intravenous injection (25 mg/kg rats, 15-30 mg/kg mice) causes fast onset and short duration of sedative action with rapid recovery when compared with midazolam.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H336

Hazard Classifications

STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML3467-SMPL:
SML3467-BULK:
SML3467-25MG:4548173372877
SML3467-5MG:4548173372884
SML3467-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system
Freyer N, Knospel F, Damm G, Greuel S, Schneider C, Seehofer D, Stohr T, Petersen KU, Zeilinger K
Drug design, development and therapy, 13, 1033-1047 (2019)
Inhaled Remimazolam Potentiates Inhaled Remifentanil in Rodents
Bevans T, Deering-Rice C, Stockmann C, Rower J, Sakata D, Reilly C
Anesthesia and Analgesia, 124, 1484-1490 (2017)
Design, Synthesis, and Biological Evaluation of Novel CNS 7056 Derivatives as Sedatives in Rats and Rabbits
Yan Liu , Xiangqing Xu , Jianyong Xie , Huan Ma , Tao Wang , Guisen Zhang , Qingeng Li
Chemical Biology & Drug Design, 88, 38-42 (2016)
CNS 7056: a novel ultra-short-acting Benzodiazepine
Anesthesiology, 107, 60-66 (2007)
Pharmacokinetics and pharmacodynamics of the short-acting sedative CNS 7056 in sheep
R N Upton , A A Somogyi, A M Martinez, J Colvill, C Grant
British Journal of Anaesthesia, 105, 798-809 (2010)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service