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Safety Information

SML3405

Sigma-Aldrich

NVP-LDZ982

≥98% (HPLC)

Synonym(s):

LDZ-982, LDZ 982, LDZ982, Methyl 5-[1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl]-3-(2,6-dichlorophenyl)isoxazole-4-carboxylate, NITD 982, NITD-982, NITD982

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About This Item

Empirical Formula (Hill Notation):
C21H11Cl3F3N3O3
CAS Number:
1357266-65-9
Molecular Weight:
516.68
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

, Light yellow to orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Dihydroorotate dehydrogenase (DHODH) inhibitor with broad-spectrum antiviral activity against Dengue, HCV, HIV, Influenza, RSV, and Yellow fever.
NVP-LDZ982 (NITD-982) is a dihydroorotate dehydrogenase (DHODH) inhibitor (Kd = 27 nM) with broad-spectrum antiviral activity by targeting host cell de novo pyrimidine biosynthesis pathway. NITD-982 inhibits various viral replications in cultues, including Dengue (DENV EC50 = 5-2.6 nM; A549), hepatitis C virus (HCV EC50 = 7-12.6 nM; Huh-7), HIV (MDR769 EC50 = 0.97 nM; PBMC), Influenza (EC50 = 32 nM/H1N1, 117 nM/B, 217 nM/H1N3; MDCK), respiratory syncytial virus (RSV EC50 = 7-9 nM; Hep-2), and Yellow fever (strain 17D EC50 = 8.2 nM; A549).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML3405-5MG:
SML3405-BULK:
SML3405-25MG:
SML3405-VAR:

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