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Safety Information

SML2880

Sigma-Aldrich

SGC-CLK-1

≥98% (HPLC)

Synonym(s):

N-(3-Methoxy-5-(trifluoromethyl)phenyl)-4-(6-methoxypyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine

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About This Item

Empirical Formula (Hill Notation):
C19H15F3N6O2
CAS Number:
748142-15-6
Molecular Weight:
416.36
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

SMILES string

FC(F)(F)C1=CC(OC)=CC(NC2=NC=CC(C3=C(C=C4)N(N=C3)N=C4OC)=N2)=C1

Biochem/physiol Actions

SGC-CLK-1 is a potent and selective CLK1/2/4 inhibitor (IC50 = 13/4/46 nM by enzyme assay; IC50 = 165/70/100 nM by cell-based NanoBRET assay) with good kinome-wide selectivity (by 403-panel KINOMEscan). SGC-CLK-1 inhibits CLK3 at significantly higher concentrations (IC50 = 363 nM by enzyme assay) and causes only partial STK16 inhibition by cell-based NanoBRET assay.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML2880-5MG:
SML2880-BULK:
SML2880-VAR:
SML2880-25MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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