Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

SML2675

Sigma-Aldrich

CuET

≥97% (HPLC)

Synonym(s):

Copper bis(N,N-diethyldithiocarbamate), Cupric diethyldithiocarbamate, Merkupral, NSC 177697, bis(N,N-Diethyldithiocarbamato)copper(II)

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C10H20CuN2S4
CAS Number:
13681-87-3
Molecular Weight:
360.09
MDL number:
MFCD00070506
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

dark green to black

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CCN(CC)C(S[Cu]SC(N(CC)CC)=S)=S

InChI

1S/2C5H11NS2.Cu/c2*1-3-6(4-2)5(7)8;/h2*3-4H2,1-2H3,(H,7,8);/q;;+2/p-2

InChI key

OBBCYCYCTJQCCK-UHFFFAOYSA-L

Biochem/physiol Actions

CuET, a metabolite of disulfiram, is an inhibitor of p97 segregase adaptor NPL4 that exhibits potent anti-cancer effects. Apparently CuET binds NPL4 and induces its aggregation, which disables the vital p97–NPL4–UFD1 pathway and induces to cell death.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

SML2675-BULK:
SML2675-VAR:
SML2675-100MG:4548173368344

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Tomoya Fujie et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 21(2), 263-273 (2016-01-31)
The interest in organic-inorganic hybrid molecules as molecular probes for biological systems has been growing rapidly. Such hybrid molecules exhibit unique biological activities. Herein, copper(II) bis(diethyldithiocarbamate) (Cu10) was found to activate the transcription factor NF-E2-related factor 2 (Nrf2), which is
Zdenek Skrott et al.
Nature, 552(7684), 194-199 (2017-12-07)
Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need for improved cancer treatment is drug repurposing. Here we highlight the potential for repurposing disulfiram (also

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service