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Safety Information

SML2573

Sigma-Aldrich

MitoCDNB

≥98% (HPLC)

Synonym(s):

[4-(5’-Chloro-2’,4’-dinitrophenylamino)but-1-yl]triphenylphosphonium methanosulfonate

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About This Item

Empirical Formula (Hill Notation):
C29H29ClN3O7PS
Molecular Weight:
630.05
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to very dark brown

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

MitoCDNB is a mitochondrially selective inactivator of mitochondrial thiol redox homeostasis in isolated cells and in vivo. MitoCDNB selectively depletes the mitochondrial reduced glutathione (GSH) pool by formation of MitoGSDNB and dramatically increasing absorbance at 328 nm. It directly inhibits mitochondrial thioredoxin TrxR2 and peroxiredoxin 3.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML2573-BULK:
SML2573-25MG:
SML2573-VAR:
SML2573-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lee M Booty et al.
Cell chemical biology, 26(3), 449-461 (2019-02-05)
Mitochondrial glutathione (GSH) and thioredoxin (Trx) systems function independently of the rest of the cell. While maintenance of mitochondrial thiol redox state is thought vital for cell survival, this was not testable due to the difficulty of manipulating the organelle's

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