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Safety Information

SML2522

Sigma-Aldrich

Diprovocim-1

≥98% (HPLC)

Synonym(s):

(3S,3′S,4S,4′S)-1,1′-(1,4-Phenylenedicarbonyl)bis[N-[(1S,2R)-2-phenylcyclopropyl]-3,4-pyrrolidinedicarboxamide, 3,4-Pyrrolidinedicarboxamide, 1,1′-(1,4-phenylenedicarbonyl)bis[N-[(1S,2R)-2-phenylcyclopropyl]-, (3S,3′S,4S,4′S)-

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About This Item

Empirical Formula (Hill Notation):
C56H56N6O6
CAS Number:
2170867-89-5
Molecular Weight:
909.08
UNSPSC Code:
51111800
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N7(C[C@H]([C@@H](C7)C(=O)N[C@@H]%10[C@H](C%10)c%11ccccc%11)C(=O)N[C@@H]8[C@H](C8)c9ccccc9)C(=O)c1ccc(cc1)C(=O)N2C[C@H]([C@@H](C2)C(=O)N[C@@H]5[C@H](C5)c6ccccc6)C(=O)N[C@@H]3[C@H](C3)c4ccccc4

InChI key

ABZBNXFGYUSVCJ-UYMKNZQYSA-N

Biochem/physiol Actions

Agonist of toll-like receptors TLR2 and TLR1
Diprovocim-1 is a potent agonist of toll-like receptors TLR2 and TLR1 with an EC50 value of 100 pM. Diprovocim-1 was shown to synergize with anti-PD-L1 treatment, inhibiting tumor growth, generating long-term antitumor memory, and curing or prolonging survival of mice engrafted with the murine melanoma B16-OVA.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML2522-BULK:
SML2522-5MG:
SML2522-25MG:
SML2522-VAR:

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Ying Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(37), E8698-E8706 (2018-08-29)
Successful cancer immunotherapy entails activation of innate immune receptors to promote dendritic cell (DC) maturation, antigen presentation, up-regulation of costimulatory molecules, and cytokine secretion, leading to activation of tumor antigen-specific cytotoxic T lymphocytes (CTLs). Here we screened a synthetic library

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