Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

SML1930

Sigma-Aldrich

CORM-401

Synonym(s):

Mn(CO)4{S2CNMe(CH2CO2H)}, Tetracarbonyl[N-(dithiocarboxy-?S,?S′)-N-methylglycine]manganate

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C8H6MnNO6S2
CAS Number:
1001015-18-4
Molecular Weight:
331.20
UNSPSC Code:
12352200
NACRES:
NA.77

form

powder

Quality Level

100

storage condition

protect from light

color

light yellow to dark yellow

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

CN(CC(O)=O)C1=S=[Mn-4]([C+]=O)([C+]=O)([C+]=O)([C+]=O)S1

Biochem/physiol Actions

CORM-401 (Mn(CO)4(S2CNMe(CH2CO2H))) is a manganese-containing carbon monoxide-releasing molecule (CORM) that generates at least three molar equivalents of CO. Due to reversible binding of CO, CORM-401 is relatively stable in solution (0.33 mol eq of CO loss after 4 h in PBS; [CORM-401] = 1 mM at time zero), while increased CO release occurs in the presence of a CO receptor or a ligand to prevent the rebinding of CO (3.2 mol eq of CO transferred to iron with a t1/2 of 0.8 min in the presence of 44 μM myoglobin; [CORM-401] = 10 μM at time zero). CO administration by CORM-401 is reported to uncouple mitochondrial respiration and inhibit glycolysis in human endothelial cells (10-100 μM), and relax isolated rat aortic rings (25 μM) pre-contracted with phenylephrine.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML1930-BULK:
SML1930-5MG:
SML1930-25MG:
SML1930-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Sian H Crook et al.
Dalton transactions (Cambridge, England : 2003), 40(16), 4230-4235 (2011-03-16)
[Mn(CO)(4){S(2)CNMe(CH(2)CO(2)H)}], 1, is shown to be a CO releasing molecule providing at least three moles CO per mole of compound. The mechanism of CO loss is dissociative and reversible and was investigated using Gaussian 09 calculations. The reversible binding of
Sarah Fayad-Kobeissi et al.
Biochemical pharmacology, 102, 64-77 (2016-01-02)
Carbon monoxide (CO) is generated by heme oxygenase-1 (HO-1) and displays important signaling, anti-apoptotic and anti-inflammatory activities, indicating that pharmacological agents mimicking its action may have therapeutic benefit. This study examined the biochemical and pharmacological properties of CORM-401, a recently
Patrycja Kaczara et al.
Biochimica et biophysica acta, 1847(10), 1297-1309 (2015-07-18)
Carbon monoxide (CO), a product of heme degradation by heme oxygenases, plays an important role in vascular homeostasis. Recent evidence indicates that mitochondria are among a number of molecular targets that mediate the cellular actions of CO. In the present

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service