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Safety Information

SML1816

Sigma-Aldrich

ABC44

≥98% (HPLC)

Synonym(s):

4-(4-Methoxyphenyl)-1-piperazinecarboxylic acid hexahydro-1,3-dioxo-7-[[1-(phenylmethyl)-4-piperidinyl]methyl]imidazo[1,5-a]pyrazin-2-yl ester, 7-((1-Benzylpiperidin-4-yl)methyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 4-(4-methoxyphenyl)piperazine-1-carboxylate

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About This Item

Empirical Formula (Hill Notation):
C31H40N6O5
CAS Number:
1831135-46-6
Molecular Weight:
576.69
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(N1OC(N2CCN(C3=CC=C(OC)C=C3)CC2)=O)C(CN(CC4CCN(CC5=CC=CC=C5)CC4)CC6)N6C1=O

Biochem/physiol Actions

ABC44 is a cell-active, potent and selective inhibitor of palmitoyl-protein thioesterase 1 (PPT-1).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML1816-VAR:
SML1816-25MG:
SML1816-5MG:
SML1816-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Armand B Cognetta et al.
Chemistry & biology, 22(7), 928-937 (2015-06-30)
Serine hydrolase inhibitors, which facilitate enzyme function assignment and are used to treat a range of human disorders, often act by an irreversible mechanism that involves covalent modification of the serine hydrolase catalytic nucleophile. The portion of mammalian serine hydrolases

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